MPEP - Moligand™, ≥98% , Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor, CAS No.96206-92-7, Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor

CAS: 96206-92-7 Cat. No.: M127959 Formule: C₁₄H₁₁N Poids moléculaire: 193.24

QUALITÉ & PURETÉ Moligand™, ≥98%

Synonyms

Pyridine, 6-methyl-2-(phenylethynyl)-|2-Picoline, 6-phenylethynyl-|2-methyl-6-(2-phenylethynyl)pyridine|MPEP|2-Methyl-6-(phenylethynyl)pyridine|2-methyl-6-(phenyl-ethynyl)pyridine|2-methyl-6-(phenylethynyl)-pyridine|[3H]-2-methyl-6-(phenylethynyl)-pyridine|2-Methyl-6-phenylethynyl-pyridine|Lopac-M-5435|2-Methyl-6-phenylethynyl-pyridine(MPEP)|6-methyl-2-(2-phenylethynyl)pyridine|Pyridine, 2-methyl-6-(phenylethynyl)-|SDCCGSBI-0050716.P002|6-Methyl-2-(phenylethynyl)pyridine|Pyridine, 2-methyl-6-(2-phenylethynyl)-

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Vue d’ensemble

MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.

Spécifications

Synonymes

Pyridine, 6-methyl-2-(phenylethynyl)- | 2-Picoline, 6-phenylethynyl- | 2-methyl-6-(2-phenylethynyl)pyridine | MPEP | 2-Methyl-6-(phenylethynyl)pyridine | 2-methyl-6-(phenyl-ethynyl)pyridine | 2-methyl-6-(phenylethynyl)-pyridine | [3H]-2-methyl-6-(phenylethynyl)-pyridine | 2-Methyl-6-phenylethynyl-pyridine | Lopac-M-5435 | 2-Methyl-6-pheny Afficher plus

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalge

Conditions de stockage de stockage

Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ALLOSTERIC MODULATOR

Mécanisme d'action

Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureté

≥98%

Noms et identifiants

Pubchem Sid

488194193

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488194193

Sourires canoniques

CC1=NC(=CC=C1)C#CC2=CC=CC=C2

IUPAC Name

2-methyl-6-(2-phenylethynyl)pyridine

InChIKey

NEWKHUASLBMWRE-UHFFFAOYSA-N

INCHI

1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3

Isomères SMILES

CC1=NC(=CC=C1)C#CC2=CC=CC=C2

Poids moléculaire

193.24

Reaxy-Rn

140513

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=140513&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Methylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Methylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Methylpyridines
• Alternative Parents: Benzene and substituted derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Methylpyridine - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as methylpyridines. These are organic compounds containing a pyridine ring substituted at one or more positions by a methyl group.
• External Descriptors: methylpyridines - acetylenic compound

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO 39 mg/mL Water <1 mg/mL Ethanol 39 mg/mL
• Sensibilité: Air sensitive;Heat sensitive
• Point de fusion (°C): 47 °C
• Poids moléculaire: 193.240 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 193.089 Da
• Monoisotopic Mass: 193.089 Da
• Topological Polar Surface Area: 12.900 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 251.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 96206-92-7, the molecular formula is C14H11N, and the molecular weight is 193.24 g/mol. InChIKey NEWKHUASLBMWRE-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.