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MSC-1186 - ≥99% , CAS No.2871698-23-4
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
MSC-1186 is a highly selective pan-SRPK inhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC 50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research of cancer
In Vitro
MSC-1186 has activity for SRPK1 and SRPK3 in HEK293T cells with EC 50 values of 98 nM and 40 nM, respectively. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC 50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 has excellent kinome-wide selectivity. MSC-1186 shows additive attenuation of SR-protein phosphorylation when is used in combination with CDC2-like kinase (CLK) inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 2.7 nM (SRPK1), 81 nM (SRPK2), 0.6 nM (SRPK3),EC50 in HEK293T cells: 98 nM (SRPK1), 40 nM (SRPK3)
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
MSC-1186 is a highly selective pan-SRPK inhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC 50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research of cancer.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥99%
Names and Identifiers
| Molecular Weight | 461.90 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 125 mg/mL (270.62 mM; Need ultrasonic) |
|---|
Solution Calculators
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Customer Reviews
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