NCX 470 - 10mM in DMSO , CAS No.1194396-71-8

CAS: 1194396-71-8 Cat. No.: N656807 Formule: C₃₁H₄₆N₂O₈ Poids moléculaire: 574.71 PubChem CID: 44462739

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma.

In Vivo

NCX 470 shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension . NCX 470 (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits. NCX 470 (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injectionDosage: 0.14% Administration: Instillation; 0.14% 30 μL; once Result: Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO medi

Conditions de stockage de stockage

Protected from light,Argon charged,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

AGONIST

Noms et identifiants

• Isomères SMILES: CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)OC(=O)CCCCCO[N+](=O)[O-])O)O
• PubChem CID: 44462739
• Poids moléculaire: 574.71