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NITD-688 - ≥99% , CAS No.2407227-31-8
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)
In Vitro
NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC 50 values of 8 to 38 nM. NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC 50 value of 0.94 nM. NITD-688 directly binds to wild-type but not mutant NS4B protein. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice . NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Infected AG129 mice Dosage: 30 mg/kg Administration: Oral gavage, twice daily for 3 days Result: Resulted in a 1.16-log reduction in viremia.
Form:Solid
IC50& Target:NS4B
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥99%
Names and Identifiers
| Isomeric SMILES | CC1(CC2=C(CN1CC3CCCCC3)C(=C(S2)NC(=O)CC4=CC=C(C=C4)S(=O)(=O)N)C#N)C |
|---|---|
| PubChem CID | 146279852 |
| Molecular Weight | 500.68 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (199.73 mM; ultrasonic and warming and heat to 60°C) |
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Solution Calculators
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