10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC 50 of 2 nM for PI3Kα .
In Vitro
NSC781406 demonstrates potent PI3K inhibition (PI3Kα IC 50 =2.0 nM) that translates into BEL-7404 cells proliferation inhibition (IC 50 =20 nM). NSC781406 displays reasonable liver microsome stability. NSC781406 demonstrates cytotoxic activities against leukemia, non-small cell, lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. It is potent against 60 cancer cell lines with a mean GI 50 value of 65 nM, and with a GI50 value less than 10 nM against four cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In the xenograft models, treatment with 30 mg/kg of NSC781406 results in statistically significant antitumor activity, with a mean reduction in relative tumor volume ratio of 52%. Sorafenib displays an inhibition ratio of 44% at 50 mg/kg. NSC781406 is well tolerated at 30 mg/kg, with no observed mortality or significant reduction of body weight . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:PI3Kα 2 nM (IC 50 ) PI3Kγ 2.7 nM (IC 50 ) PI3Kβ 9.4 nM (IC 50 ) PI3Kδ 14 nM (IC 50 ) mTOR 5.4 nM (IC 50 )
| Isomeric SMILES | COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C#CCN4CCN(CC4)S(=O)(=O)C)NS(=O)(=O)C5=C(C=C(C=C5)F)F |
|---|---|
| PubChem CID | 127025628 |
| Molecular Weight | 627.68 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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