Oligomycin C - ≥95% , CAS No.11052-72-5

CAS: 11052-72-5 Cat. No.: O329491 Molecular Weight: 775.06 Beilstein Registry Number: 1417374 EC Number: 234-276-0

GRADE & PURITY ≥95%

Synonyms

(1S,4E,5'R,6R,6'R,7S,8R,10S,11R,12R,14R,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-Ethyl-7,11,15-trihydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione | 22-Et

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Oligomycin C is part of a class of macrolide antibiotics and is a potent inhibitor of cell regulatory volume decrease (RVD). Oligomycin has been shown to inhibit ATP synthase by blocking the ATP5 (mitochondrial F|1|F|0|-ATPase). Doxorubicin-resistant HepG2 cell studies report that oligomycin can inhibit the activity of P-glycoprotein and induce apoptosis.

Specifications

Synonyms

(1S, 4E, 5'R, 6R, 6'R, 7S, 8R, 10S, 11R, 12R, 14R, 15R, 16S, 18E, 20E, 22S, 25R, 27S, 28R, 29S)-22-Ethyl-7, 11, 15-trihydroxy-6'-[(2S)-2-hydroxypropyl]-5', 6, 8, 10, 12, 14, 16, 28, 29-nonamethylspiro[2, 26-dioxabicyclo[23.3.1]nonacosa-4, 18, 20-triene-27, 2'-oxane]-3, 9, 13-trione | 22-Et

Specifications & Purity

≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)C)C)O)C)C)O)C)C
• IUPAC Name: 22-ethyl-7,11,15-trihydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
• InChIKey: CMMLZMMKTYEOKV-UHFFFAOYSA-N
• INCHI: 1S/C45H74O10/c1-12-35-17-15-13-14-16-26(3)39(48)30(7)41(50)32(9)43(52)33(10)42(51)31(8)40(49)27(4)18-21-38(47)53-44-29(6)36(20-19-35)54-45(34(44)11)23-22-25(2)37(55-45)24-28(5)46/h13-15,17-18,21,25-37,39-40,43-44,46,48-49,52H,12,16,19-20,22-24H2,1-11H3
• Isomeric SMILES: CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)C)C)O)C)C)O)C)C
• WGK Germany: 3
• RTECS: RK3335000
• Molecular Weight: 775.06
• Beilstein: 1417374
• Reaxy-Rn: 25310926
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25310926&ln=

Chemical and Physical Properties

• Solubility: Soluble in 100% ethanol, methanol, DMF, and DMSO. Insoluble in water.
• Refractive Index: n20D1.54 (Predicted)
• Boil Point(°C): 876.18° C at 760 mmHg (Predicted)
• Melt Point(°C): 195-200° C