Determine the necessary mass, volume, or concentration for preparing a solution.
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≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Paeonol is an active ingredient isolated from Paeonia suffruticosa Andr. Its pharmacologic functions include antiaggregatory, anti-inflammatory and anti-ischemia reperfusion damage and anti-lipid peroxidation effects.
An anti-inflammatory & anti-lipid peroxidation agent
| Pubchem Sid | 488181255 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488181255 |
| Canonical Smiles | CC(=O)C1=C(C=C(C=C1)OC)O |
| IUPAC Name | 1-(2-hydroxy-4-methoxyphenyl)ethanone |
| InChIKey | UILPJVPSNHJFIK-UHFFFAOYSA-N |
| INCHI | 1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 |
| Isomeric SMILES | CC(=O)C1=C(C=C(C=C1)OC)O |
| WGK Germany | 3 |
| RTECS | RT1215000 |
| Molecular Weight | 166.17 |
| Beilstein | 8267 |
| Reaxy-Rn | 1282794 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1282794&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Class | Organooxygen compounds |
| Subclass | Carbonyl compounds |
| Intermediate Tree Nodes | Ketones - Aryl ketones - Phenylketones |
| Direct Parent | Alkyl-phenylketones |
| Alternative Parents | Methoxyphenols Acetophenones Phenoxy compounds Methoxybenzenes Benzoyl derivatives Aryl alkyl ketones Anisoles Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Alkyl-phenylketone - Methoxyphenol - Acetophenone - Phenoxy compound - Anisole - Benzoyl - Phenol ether - Aryl alkyl ketone - Methoxybenzene - Phenol - 1-hydroxy-4-unsubstituted benzenoid - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Vinylogous acid - Ether - Hydrocarbon derivative - Organic oxide - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. |
| External Descriptors | phenols - methoxybenzene |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Oct 29, 2025 | H111081 | |
| Certificate of Analysis | Oct 29, 2025 | H111081 | |
| Certificate of Analysis | Oct 29, 2025 | H111081 | |
| Certificate of Analysis | Jun 16, 2025 | H111081 | |
| Certificate of Analysis | Jun 12, 2025 | H111081 | |
| Certificate of Analysis | May 09, 2025 | H111081 | |
| Certificate of Analysis | May 09, 2025 | H111081 | |
| Certificate of Analysis | May 09, 2025 | H111081 | |
| Certificate of Analysis | May 09, 2025 | H111081 | |
| Certificate of Analysis | May 09, 2025 | H111081 | |
| Certificate of Analysis | Apr 29, 2025 | H111081 | |
| Certificate of Analysis | Sep 20, 2023 | H111081 | |
| Certificate of Analysis | Sep 20, 2023 | H111081 | |
| Certificate of Analysis | Sep 20, 2023 | H111081 | |
| Certificate of Analysis | Sep 20, 2023 | H111081 | |
| Certificate of Analysis | Sep 06, 2023 | H111081 | |
| Certificate of Analysis | Jun 06, 2023 | H111081 | |
| Certificate of Analysis | Feb 10, 2023 | H111081 | |
| Certificate of Analysis | Feb 10, 2023 | H111081 | |
| Certificate of Analysis | May 25, 2022 | H111081 | |
| Certificate of Analysis | May 25, 2022 | H111081 | |
| Certificate of Analysis | May 25, 2022 | H111081 | |
| Certificate of Analysis | May 09, 2022 | H111081 | |
| Certificate of Analysis | Dec 14, 2021 | H111081 | |
| Certificate of Analysis | Dec 14, 2021 | H111081 |
| Solubility | Soluble in water (<1 mg/ml at 25 °C), methanol, DMSO (33 mg/ml at 25 °C), and ethanol (33 mg/ml at 25 °C). |
|---|---|
| Refractive Index | 1.54 |
| Flash Point(°F) | 235.4 °F |
| Flash Point(°C) | 113 °C |
| Boil Point(°C) | 154°C/20mmHg |
| Melt Point(°C) | 47-50°C |
| Molecular Weight | 166.170 g/mol |
| XLogP3 | 2.000 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 2 |
| Exact Mass | 166.063 Da |
| Monoisotopic Mass | 166.063 Da |
| Topological Polar Surface Area | 46.500 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 167.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Chen Chen, Xiao Yang, Xian-hui Shao, Yue Zhou, Xiao-bin Zhang, Yun-ping Lu, Meng-zhen Xing, Qing-chang Xia, Yuan-xiang Liu, Yu-ning Ma, Ting-ting Zheng, Lin-lin Zhang, Yu-xia Ma, Ji-guo Yang. (2023) Thermal-grinding supramolecular network loaded with paeonol for treatment of skin eczema. CHEMICAL ENGINEERING SCIENCE, [PMID:] [10.1016/j.ces.2023.119096] |
| 2. Xin Li, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Yachun Zheng, Shiquan Chang, Li Gao, Guoping Zhao. (2023) Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS Neuroscience & Therapeutics, [PMID:37032648] [10.1111/cns.14211] |
| 3. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
| 4. Songjun Liu, Xinran Cao, Tao Zhang, Chenyang Zhang, Jiao Qu, Yang Sun, Wen Lv, Fan Qu. (2022) Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. PHYTOMEDICINE, [PMID:36610113] [10.1016/j.phymed.2022.154593] |
| 5. Siying Wang, Lanlan Xie, Qilei Yang, Yuting Geng, Hedi Kang, Xiuhua Zhao. (2022) Extraction and purification of paeonol from Moutan Cortex by a combined method of steam distillation and antisolvent recrystallization to reduce energy consumption and carbon dioxide emissions. CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 101 (7): (3771-3785). [PMID:] [10.1002/cjce.24732] |
| 6. Yuling Wang, Zeyan Tang, Xueping Guo, Yuqi Zhao, Shujing Ren, Zhenhai Zhang, Huixia Lv. (2022) Hyaluronic acid-cyclodextrin encapsulating paeonol for treatment of atopic dermatitis. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:35714817] [10.1016/j.ijpharm.2022.121916] |
| 7. Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian. (2022) Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities. PEST MANAGEMENT SCIENCE, 78 (8): (3442-3455). [PMID:35567371] [10.1002/ps.6985] |
| 8. Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing. (2022) Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila. FISH & SHELLFISH IMMUNOLOGY, [PMID:35314333] [10.1016/j.fsi.2022.03.005] |
| 9. Yue-E Tian, Di Sun, Xiao-Xiao Han, Jin-Ming Yang, Song Zhang, Nan-Nan Feng, Li-Na Zhu, Zhong-Yuan Xu, Zhi-Ping Che, Sheng-Ming Liu, Xiao-Min Lin, Jia Jiang, Gen-Qiang Chen. (2021) Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, [PMID:32009450] [10.1080/10286020.2020.1718116] |
| 10. Chunqing Niu, Xiang Li, Yiyu Wang, Xinyu Liu, Jian Shi, Xinyu Wang. (2019) Design and performance of a poly(vinyl alcohol)/silk fibroin enzymatically crosslinked semi-interpenetrating hydrogel for a potential hydrophobic drug delivery. RSC Advances, 9 (70): (41074-41082). [PMID:35540084] [10.1039/C9RA09344C] |
| 11. Jingjing Yao, Yangxin Zhang, Qiming Hu, Decheng Zeng, Fang Hua, Wei Meng, Weiyun Wang, Guan-Hu Bao. (2017) Optimization of paeonol-loaded poly(butyl-2-cyanoacrylate) nanocapsules by central composite design with response surface methodology together with the antibacterial properties. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:28189814] [10.1016/j.ejps.2017.01.028] |
| 12. Jingjing Yao, Decheng Zeng, Yangxin Zhang, Dongdong Sun, Endong Yang, Haiping Liu, Feng Guo, Weiyun Wang. (2016) Effect of solvents on forming poly(butyl-2-cyanoacrylate) encapsulated paeonol nanocapsules. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:27846779] [10.1080/09205063.2016.1262161] |
| 13. Xie Xiaoyu, Pan Xiaoyan, Han Shengli, Wang Sicen. (2015) Development and characterization of magnetic molecularly imprinted polymers for the selective enrichment of endocrine disrupting chemicals in water and milk samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407 (6): (1735-1744). [PMID:25577356] [10.1007/s00216-014-8425-0] |
| 14. Ping Mao, Xiao Wei, Mo Liqian, Xiao Xiaoyan, Song Shaolian, Tang Waijiao, Yang Xixiao. (2014) Paeonol Attenuates Advanced Oxidation Protein Product-Induced Oxidative Stress Injury in THP-1 Macrophages. PHARMACOLOGY, [PMID:25170865] [10.1159/000363577] |
| 15. Xin Li, Zifeng Zhuang, Yuting Hao, Shaozi Lin, Junyan Gu, Shiquan Chang, Lin Lan, Guoping Zhao, Di Zhang. (2025) Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26 (9): (3964). [PMID:40362205] [10.3390/ijms26093964] |
| 16. Miao Li, Na Gao, Lei Xu, Peng Ge, Nan Jiang, Yuhong Shang. (2025) Integrative RNA-seq and LASSO-COX analysis reveal Paeonol’s key target gene in proliferation suppression and apoptosis-induced in cervical cancer. Frontiers in Pharmacology, [PMID:41126956] [10.3389/fphar.2025.1646473] |
| 17. Xu Chen, Jianxing Liu, Yongrui Liang, Zihan Gong. (2026) Paeonol inhibits the progression of endometrial cancer by affecting TRIM26-mediated LDHA ubiquitination modification. TISSUE & CELL, [PMID:41691946] [10.1016/j.tice.2026.103359] |
| 18. Liu-Jie Qi, Zhao-Qi Zhang, Zhong-Na Zhang, Jing-An Li, Shao-Kang Guan. (2026) Theoretical calculation-experimental collaborative design of integrated coating for degradation regulation and diagnosis-treatment of magnesium alloy for cerebrovascular stents. Journal of Advanced Research, [PMID:41713732] [10.1016/j.jare.2026.02.028] |