Pitavastatin - Moligand™, 10 mM in DMSO , CAS No.147511-69-1

CAS: 147511-69-1 Cat. No.: P1499322 Formule: C₂₅H₂₄FNO₄ Poids moléculaire: 421.46 Numéro CE: 643-092-3 PubChem CID: 5282452

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

Specifications

Spécifications et pureté

Moligand™, 10 mM in DMSO

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Noms et identifiants

• Isomères SMILES: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F
• PubChem CID: 5282452
• Poids moléculaire: 421.46

Propriétés chimiques et physiques

• Point d'éclair (°C): 372.3±31.5 ℃
• Point d'ébullition (°C): 692.0±55.0℃ at 760 mmHg

Références

1. Anning Yang, Hongwen Zhang, Huiping Zhang, Nan Li, Cong Chen, Xiaoling Yang, Jue Tian, Jianmin Sun, Guizhong Li, Yue Sun, Bin Liu, Yideng Jiang.  (2025)  Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition.  JOURNAL OF CONTROLLED RELEASE,      [PMID:40043912] [10.1016/j.jconrel.2025.113598]

2. Yizhou Wu, Hongyan Zhou, Hao Liu, Jiayao Hu, Yue Sun, Wei Yan, Chunyi Tong, Ying Kong, Bin Liu.  (2025)  Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux.  Acta Pharmaceutica Sinica B,      [PMID:40654339] [10.1016/j.apsb.2024.08.006]