PQ 401 - Moligand™, 10mM in DMSO , Inhibitor of Insulin-like growth factor I receptor, CAS No.196868-63-0, Inhibitor of Insulin-like growth factor I receptor

CAS: 196868-63-0 Cat. No.: P408859 Formule: C₁₈H₁₆ClN₃O₂ Poids moléculaire: 341.79 Numéro CE: 633-729-3

QUALITÉ & PURETÉ Moligand™, 10mM in DMSO

Synonyms

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

PQ 401 PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
In vitro

PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.

In vivo

PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.
Cell Data

cell lines：

Concentrations：~50 μM

Incubation Time：3 days

Powder Purity:≥99%

Spécifications

Synonymes

N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of Insulin-like growth factor I receptor

Noms et identifiants

Isomères SMILES

CC1=NC2=CC=CC=C2C(=C1)NC(=O)NC3=C(C=CC(=C3)Cl)OC

WGK Allemagne

3

Poids moléculaire

341.79

Reaxy-Rn

14012784

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14012784&ln=

Cibles associées (humaines)

IGF1R Tclin Insulin-like growth factor 1 receptor (1 Activities)

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Point de fusion (°C): 190 °C(dec.)

Foire aux questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 196868-63-0, the molecular formula is C18H16ClN3O2, and the molecular weight is 341.79 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.