Primidone - Moligand™, 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.125-33-7, Sodium channel alpha subunit blocker

CAS: 125-33-7 Cat. No.: P408422 Molecular Weight: 218.25 Beilstein Registry Number: 24(5)102 EC Number: 204-737-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NCI-C56360 | 5-​ethyldihydro-​5-​phenyl-4,​6(1H,​5H)​-​pyrimidinedione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Primidone Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonyms

NCI-C56360 | 5-​ethyldihydro-​5-​phenyl-4, ​6(1H, ​5H)​-​pyrimidinedione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER, POSITIVE ALLOSTERIC MODULATOR

Mechanism of action

Sodium channel alpha subunit blocker

Product Properties

• ALogP: 0.9

Names and Identifiers

• Isomeric SMILES: CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
• RTECS: UV9100000
• UN Number: 3249
• Packing Group: II
• Molecular Weight: 218.25
• Beilstein: 24(5)102
• Reaxy-Rn: 218034
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=218034&ln=

Associated Targets(Human)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (1 Activities)

Discover Target: TRPM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Refractive Index: 1.53
• Boil Point(°C): 520.70° C
• Melt Point(°C): 281°C

References

1. Danni Cui, Huan He, Wenxiao Xie, Shanshan Yang, Ziwei Guo, Zhicheng Liao, Feng Liu, Chaochao Lai, Xiaomin Ren, Bin Huang, Xuejun Pan.  (2023)  Occurrence and cycle of dissolved iron mediated by humic acids resulting in continuous natural photodegradation of 17α-ethinylestradiol.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:38091802] [10.1016/j.jhazmat.2023.133155]

2. Xiuzhen Wei, Xiaoyan Bao, Jiawei Wu, Cuixia Li, Yingying Shi, Jinyuan Chen, Bosheng Lv, Baoku Zhu.  (2018)  Typical pharmaceutical molecule removal behavior from water by positively and negatively charged composite hollow fiber nanofiltration membranes.  RSC Advances,  8  (19): (10396-10408).  [PMID:35540449] [10.1039/C8RA00519B]