Ro24-7429 - ≥98% , Human immunodeficiency virus type 1 Tat protein antagonist, CAS No.139339-45-0, Human immunodeficiency virus type 1 Tat protein antagonist

CAS: 139339-45-0 Cat. No.: R651352 Formule: C₁₄H₁₃ClN₄ Poids moléculaire: 272.73

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects

In Vitro

Ro 24-7429 (0.1-5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner. ?\nRo 24-7429 (1-25 μM) also induces apoptosis and inhibits antigen-induced lymphocyte proliferation. ?\nRo24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Peripheral blood mononuclear cells (PBMCs) Concentration: 0.1 μM, 1 μM, 5 μM Incubation Time: 3 days Result: Induced a dose-dependent increase in apoptosis of cultured PBMCs.

In Vivo

Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J male and female mice (aged 6 to 8 weeks) induced by BleomycinDosage: 17.5 mg/kg, 35 mg/kg, and 70 mg/kg Administration: i.p.; daily; for 14 or 21 days Result: Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.

Form:Solid

IC50& Target:HIV-1

Specifications

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Mécanisme d'action

Human immunodeficiency virus type 1 Tat protein antagonist

Pureté

≥98%

Noms et identifiants

Sourires canoniques

CNC1=NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1

Poids moléculaire

272.73

Propriétés chimiques et physiques

• Solubilité: DMSO : 62.5 mg/mL (229.16 mM; Need ultrasonic)

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 139339-45-0, the molecular formula is C14H13ClN4, and the molecular weight is 272.73 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.