Sapacitabine - 10mM in DMSO , DNA inhibitor, CAS No.151823-14-2, DNA inhibitor

CAS: 151823-14-2 Cat. No.: S655671 Formule: C₂₆H₄₂N₄O₅ Poids moléculaire: 490.64 PubChem CID: 153970

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.

In Vitro

Concentrations of Sapacitabine required to achieve an IC 50 range from 3±0.6 μM for the colon cancer cell line HCT116 to 67±14 μM for the breast cancer cell line MDA-MB-435. Cell cycle analysis shows that 35% Sapacitabine-treated cells are arrested in late-S phase and 41% in G 2 /M phase. L1210 cells with deoxycytidine kinase (dCK) activity are sensitive to Sapacitabine, (IC 50 20±6 μM). In the docetaxel/Sapacitabine combinations, synergistic effects (CI<1) are observed when docetaxel is given before Sapacitabine in both cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

On Day 14, the Sapacitabine (5 mg/kg)+vorinostat (33 mg/kg) group has a mean tumour volume of 245 mm 3 and a tumour growth inhibition (TGI) of 92%, whereas the Sapacitabine (15 mg/kg)+vorinostat (33 mg/kg) group has a mean tumour volume of 107 mm 3 and a TGI of 112%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

Female (nu/nu) mice are injected subcutaneously with 1×10 7 MV4-11 cells resuspended in 50% Matrigel at a single site on their flanks. Once tumour volumes are 126 to 256 mm 3 (16 days post-implantation) animals are pair matched by tumour size into treatment groups (minimum of six mice per group) with a mean tumour size of ~190 mm 3 . Tumour measurements are calculated using the formula: volume (mm 3 )=width 2 (mm)×length (mm)×0.5. Sapacitabine is administered once a day orally (5 or 15 mg/kg) for 4 days , followed by a 3-day break before another 4 days of treatment; dosing starts on the same day as distribution to the treatment groups . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:nucleoside analog

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Mécanisme d'action

DNA inhibitor

Propriétés du produit

• ALogP: 5.2

Noms et identifiants

• Isomères SMILES: CCCCCCCCCCCCCCCC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)C#N
• CAS alternatif: 151823-14-2
• PubChem CID: 153970
• Termes d'entrée MeSH: 2'-C-cyano-2'-deoxy-1-arabinofuranosyl-N(4)-palmitoylcytosine;CNDAC cpd;CS-682;CYC 682;CYC-682;sapacitabine
• Poids moléculaire: 490.64

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 151823-14-2, the molecular formula is C26H42N4O5, and the molecular weight is 490.64 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.