SB 334867 - Moligand™, ≥98% , Antagonist of OX 1 receptor;Antagonist of OX 2 receptor, CAS No.792173-99-0, Antagonist of OX 1 receptor;Antagonist of OX 2 receptor

CAS: 792173-99-0 Cat. No.: S274650 Formule: C₁₇H₁₃N₅O₂ Poids moléculaire: 319.32 Numéro CE: 110-450-0 PubChem CID: 6604926

GRADE & PURITY Moligand™, ≥98%

Synonyms

SCHEMBL496853 | AC-32752 | DTXSID60143346 | Q7388911 | SR-01000597554 | EX-A444 | 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea | MFCD06411602 | EX-8460 | 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hydrochloride | SB-334,867 | 1

Storage

A conserver à -20°C,Desséché

Shipped In

Glacière + blocs de glace

Vue d’ensemble

Le SB-334867 est un antagoniste sélectif du récepteur de l'orexine-1 (OX1).

Specifications

Synonymes

SCHEMBL496853 | AC-32752 | DTXSID60143346 | Q7388911 | SR-01000597554 | EX-A444 | 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea | MFCD06411602 | EX-8460 | 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hydrochloride | SB-334,867 | 1

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

Antagoniste sélectif du récepteur OX 1. Inhibe la libération intracellulaire de calcium induite par l'orexine-A (IC 50 = 226 nM). Présente des effets anxiolytiques, sédatifs et anorexigènes in vivo.

Conditions de stockage de stockage

A conserver à -20°C,Desséché

Expédié en

Glacière + blocs de glace

Grade

Moligand™

Type d'action

ANTAGONIST

Mécanisme d'action

Antagonist of OX 1 receptor;Antagonist of OX 2 receptor

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%

Noms et identifiants

Pubchem Sid

488195852

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488195852

Sourires canoniques

CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4

IUPAC Name

1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea

InChIKey

AKMNUCBQGHFICM-UHFFFAOYSA-N

INCHI

1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)

Isomères SMILES

CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4

PubChem CID

6604926

Poids moléculaire

319.32

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Naphthyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Naphthyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthyridines
• Alternative Parents: Benzoxazoles Pyridines and derivatives Benzenoids Oxazoles Heteroaromatic compounds Ureas Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Naphthyridine - Benzoxazole - Pyridine - Benzenoid - Azole - Oxazole - Heteroaromatic compound - Carbonic acid derivative - Urea - Oxacycle - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as naphthyridines. These are compounds containing a naphthyridine moiety, a naphthalene in which a carbon atom has been replaced by a nitrogen in each of the two rings. The naphthyridine skeleton can also be described as an assembly two fused pyridine rings, which do not share their nitrogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in ethanol to 10 mM and in DMSO to 100 mM
• Poids moléculaire: 319.320 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 319.107 Da
• Monoisotopic Mass: 319.107 Da
• Topological Polar Surface Area: 92.900 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 462.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1