SERCA2a activator 1 - ≥99% , CAS No.2139330-34-8

CAS: 2139330-34-8 Cat. No.: S651392 Formule: C₃₂H₂₉N₃O₄S Poids moléculaire: 551.66

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca 2+ -dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure

In Vitro

SERCA2a activator 1 (Compound A) activates the Ca 2+ -dependent ATPase activity of cardiac sarcoplasmic reticulum (SR) vesicles but not that of skeletal muscle SR vesicles that lack phospholamban (PLN). The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation. SERCA2a activator 1 also increases the Ca 2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. In isolated perfused rat hearts, the SERCA2a activator 1 enhances systolic and diastolic functions. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SERCA2a activator 1 (Compound A; 30mg/kg; intravenous injection; male Wistar rats) treatment significantly enhances the diastolic function in anesthetized normal rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (7-8 weeks old) Dosage: 30mg/kg Administration: Intravenous injection Result: Significantly enhanced the diastolic function in anesthetized normal rats.

Form:Solid

IC50& Target:SERCA2a

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca 2+ -dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 c

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

• Sourires canoniques: O=C(C1=CC(C(C=C2CC3=CC=CC=C3)=CN(CCCC)C2=O)=NC=C1)NS(=O)(C4=CC=C5C=CC=CC5=C4)=O
• Poids moléculaire: 551.66

Propriétés chimiques et physiques

• Solubilité: DMSO : 62.5 mg/mL (113.29 mM; ultrasonic and warming and heat to 80°C)