SP4206 - ≥98% , CAS No.515846-21-6

CAS: 515846-21-6 Cat. No.: S650734 Molecular Weight: 662.56

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity ( K d =70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα ( K d =10 nM)

In Vitro

SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC 50 s of 68.8, 80.1, 117.0, and 10.4 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IL-2 70 nM (Kd)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity ( K d =70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα ( K d =10 nM).

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: O=C(C1=CC=C(COC2=CC=C(C3=NN(C)C(C4CCN(C(CNC([C@@H](CC(C)C)NC(N)=N)=O)=O)CC4)=C3)C(Cl)=C2Cl)O1)O
• Molecular Weight: 662.56

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (150.93 mM; Need ultrasonic)