Sunitinib-d4 , CAS No.1126721-79-6

CAS: 1126721-79-6 Cat. No.: S648316 Formule: C₂₂H₂₃D₄FN₄O₂ Poids moléculaire: 402.50

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Sunitinib-d 4 is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ , respectively.Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spécifications

Mécanismes biochimiques et physiologiques

Sunitinib-d 4 is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ , respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibi

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

Sourires canoniques

C(=C\\1/C=2C(NC1=O)=CC=C(F)C2)\\C3=C(C)C(C(NC(C(N(CC)CC)([2H])[2H])([2H])[2H])=O)=C(C)N3

Poids moléculaire

402.50