Tenofovir - Moligand™, 10mM in DMSO , DNA polymerase/reverse transcriptase inhibitor, CAS No.147127-20-6, DNA polymerase/reverse transcriptase inhibitor

CAS: 147127-20-6 Cat. No.: T409276 Molecular Weight: 287.22 EC Number: 604-571-2 PubChem CID: 464205

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

GS-1278 | (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Tenofovir (GS-1278) blocksreverse transcriptaseand hepatitis B virus infections.
In vitro

Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT.

In vivo

Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.
Cell Data

cell lines：NSCLC cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

GS-1278 | (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

DNA polymerase/reverse transcriptase inhibitor

Product Properties

• ALogP: -1.6

Names and Identifiers

• Isomeric SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
• Alternate CAS: 206184-49-8
• PubChem CID: 464205
• Molecular Weight: 287.22

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Ethanol: mg/mL
• Specific Rotation[α]: -20° (C=1,0.1mol/L HCl)
• Melt Point(°C): 283 °C