Thioflavin T , CAS No.2390-54-7

CAS: 2390-54-7 Cat. No.: T168914 Molecular Weight: 318.86 EC Number: 219-228-9 PubChem CID: 16953

Synonyms

Setoflavine T | Basic yellow 1

Storage

Protected from light,Room temperature

Shipped In

Normal

Overview

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid.Thioflavin T has been used in histology and for protein characterization.
Usually used to identify the presence of amyloid fibrils in samples.

Specifications

Synonyms

Setoflavine T | Basic yellow 1

Biochemical and Physiological Mechanisms

Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo . Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water.

Storage

Protected from light, Room temperature

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

• Pubchem Sid: 488182319
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488182319
• Canonical Smiles: CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]
• IUPAC Name: 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride
• InChIKey: JADVWWSKYZXRGX-UHFFFAOYSA-M
• INCHI: 1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
• Isomeric SMILES: CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]
• Alternate CAS: 2390-54-7
• PubChem CID: 16953
• Molecular Weight: 318.86

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Benzothiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Benzothiazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzothiazoles
• Alternative Parents: Dialkylarylamines Aniline and substituted anilines Thiazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organic chloride salts Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,3-benzothiazole - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Thiazole - Azole - Tertiary amine - Azacycle - Hydrocarbon derivative - Organic salt - Organopnictogen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Organic chloride salt - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzothiazoles. These are organic compounds containing a benzene fused to a thiazole ring (a five-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).
• External Descriptors: organic chloride salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

BCHE Tclin Butyrylcholinesterase (7174 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: solubility in MeOH Clear to Very Slightly Hazy，Yellow to Yellow-Green，1 mg/mL
• Sensitivity: Moisture & light sensitive
• Molecular Weight: 318.900 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 318.096 Da
• Monoisotopic Mass: 318.096 Da
• Topological Polar Surface Area: 35.400 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 325.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

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61. Xueqing He, Songyi Lin, Lei Chen, Yihan Huang, Jinhui Hu, Na Sun.  (2025)  Antarctic Krill Protein Amyloid Fibrils as a Novel Iron Carrier for the Improvement of Iron Deficiency.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39851240] [10.1021/acs.jafc.4c11046]

62. Yixin Li, Zitong Wang, Jiaqi Wu, Jie Zheng, Fu Liu, Juanying Ou, Caihuan Huang, Shiyi Ou.  (2024)  Catalytic elevation effect of methylglyoxal on invertase and characterization of MGO modification products.  FOOD CHEMISTRY,      [PMID:39142204] [10.1016/j.foodchem.2024.140749]

63. Lina Bao, Wanchun Luo, Qinying Li, Yu Zhang, Zitong Zhang, Xi Li, Le Wang, Jintao Zhang, Kun Huang, Xu Yu, Li Xu.  (2024)  Chiral carbon dots based on ternary carbon sources: A multifunctional therapeutic agent for Cu2+-induced Alzheimer's disease.  CARBON,      [PMID:] [10.1016/j.carbon.2024.119333]

64. Jiaxu Wang, Zhengrong Lu, Zhanmin Liu, Qiming Chen.  (2025)  Colorimetric and fluorescent dual-modality assay for cell-free mitochondrial DNA copy number in saliva.  ANALYTICAL BIOCHEMISTRY,      [PMID:40081642] [10.1016/j.ab.2025.115840]

65. Kun Li, Jiaqi Zhang, Yifan Li, Zirong Li, Jun Wang, Yuanyuan Yu, Qiang Wang, Ping Wang.  (2024)  Conjugation of chitosan oligosaccharide to papain for controllable anti-felting finishing of wool textiles.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2024.119531]

66. Cao Xiuyun, Fan Tiange, Shao Xu, Wang Chao, Wang Xin, Guan Ping, Hu Xiaoling.  (2024)  Controlled preparation of tannic acid–derived carbonized dots and their use to inhibit amyloid aggregation and promote aggregate disaggregation.  MICROCHIMICA ACTA,  191  (10): (1-13).  [PMID:39227417] [10.1007/s00604-024-06646-0]

67. Wei Yuxin, Bai Qingqing, Ning Xinlu, Bai Xiaofan, Lv Jie, Li Meng.  (2024)  Covalent organic framework derived single-atom copper nanozymes for the detection of amyloid-β peptide and study of amyloidogenesis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:39681699] [10.1007/s00216-024-05683-1]

68. Hui-Han Ma, Jia-Yi Zheng, Yu-Hui Qiu, Shan Su, Fang-Mei Lu, Guang-Liang Wu, Shi-Jie Zhang, Ye-Feng Cai.  (2024)  Dengzhan Shengmai capsule ameliorates cognitive impairment via inhibiting ER stress in APP/PS1 mice.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39505222] [10.1016/j.jep.2024.119016]

69. Jinhong Gao, Heng Du, Zhenhong Zhang, Qunpeng Duan, Libo Yuan, Bingchao Duan, Hongyan Yang, Kui Lu.  (2025)  Design and Characterization of Peptide-Based Self-Assembling Microgel for Encapsulation of Sesaminol.  Foods,  14  (6): (971).  [PMID:40231992] [10.3390/foods14060971]

70. Dongsheng Ji, Jiahui Zhang, Jihai Liang, Zhi-Shu Huang, Bing Shu, Ding Li.  (2025)  Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid.  Redox Biology,      [PMID:40121956] [10.1016/j.redox.2025.103600]

71. Liu Shanshan, Wang Yiran, Xiang Fan, Chen Yanmei, Li Jing, Lin Junqi, Ruan Zhijun.  (2024)  Fluorescent and polarity-switchable photoelectrochemical dual-mode homogeneous sensing platform for ultrasensitive kanamycin detection based on EXO III–driven signal amplification.  MICROCHIMICA ACTA,  191  (10): (1-12).  [PMID:39284945] [10.1007/s00604-024-06679-5]

72. Liang Zhang, Jie Zhan, Xiayu Liu, Boyuan Guan, Peichao Zhang, Deshang Zhang, Wenjun Wang, Guanchen Liu, Hui Zhang, Donghong Liu.  (2024)  Functionalization of oilseed proteins via fibrillization: Comparison in structural characteristics, digestibility and 3D printability of amyloid fibrils.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2024.111019]

73. Haoqiang Wang, Wen Li, Shunjing Luo, Xiuting Hu, Chengmei Liu.  (2024)  Gelling ability and gel structure of soy protein isolate influenced by heating in the presence of various acids.  FOOD CHEMISTRY,      [PMID:39454439] [10.1016/j.foodchem.2024.141745]

74. Tianyao Li, Jiaxin Chen, Zhouyuan Xie, Jiansong Fang, Qiqing Wu, Xinyue Cao, Ziying Chen, Yiyun Wang, Qiqi Fan, Qi Wang, Jinman Liu.  (2025)  Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway.  Frontiers in Pharmacology,      [PMID:40066331] [10.3389/fphar.2025.1528590]

75. Lu Lv, Liyuan Zhang, Zhengyang Pan, Chunhui Yin, Jingyi He, Zhihao Wang, Huixiang Cheng, Leiliang Zhang.  (2024)  G-Quadruplexes in hemorrhagic fever viruses of Bunyavirales.  Future Virology,      [PMID:] [10.1080/17460794.2024.2351737]

76. Shuyu Zhu, Shiying Zhou, Liyuan Deng, Tao Gu, Jiawei Li, Jian Chen, Xuemei Wang, Changjun Hou, Danqun Huo.  (2024)  Hairpin probe-based one-pot multiplex isothermal amplification combined with bifunctional G-quadruplex (IHP-GT) for the detection of alkaline phosphatase.  ANALYTICA CHIMICA ACTA,      [PMID:39396314] [10.1016/j.aca.2024.343255]

77. Qixin Shi, Yingqun Nian, Yang You, Ziyan Li, Yunqi Li, Ran Zhao, Zhengzhi Chen, Tianhang Huang, Bing Hu.  (2024)  Heterogeneity in Diameters of Protein Fibrils and Chitosan for a High CO2/O2 Selectivity and Desired Mechanical Properties of Edible Bioplastic Films.  Small,      [PMID:39655379] [10.1002/smll.202405346]

78. Xiangyuan Zhao, Chunyan Yang, Wei Liu, Ke Lu, Hao Yin.  (2024)  Inhibition of insulin fibrillation by carboxyphenylboronic acid-modified chitosan oligosaccharide based on electrostatic interactions and hydrophobic interactions.  BIOPHYSICAL CHEMISTRY,      [PMID:38615538] [10.1016/j.bpc.2024.107236]

79. Qianhua Feng, Xueli Zhang, Xiaowen Zhao, Jia Liu, Qing Wang, Yuqi Yao, Huifang Xiao, Yucui Zhu, Wenwen Zhang, Lei Wang.  (2024)  Intranasal Delivery of Pure Nanodrug Loaded Liposomes for Alzheimer's Disease Treatment by Efficiently Regulating Microglial Polarization.  Small,      [PMID:39370581] [10.1002/smll.202405781]

80. Wang Chao, Shao Xu, Fan Tiange, Cao Xiuyun, Wang Xin, Guan Ping, Hu Xiaoling.  (2024)  Ionic liquid-functionalized carbon dots for inhibiting amyloid aggregation and oxidative stress.  JOURNAL OF MATERIALS SCIENCE,  59  (30): (13948-13960).  [PMID:] [10.1007/s10853-024-09564-x]

81. Lidong Pang, Qunchao Su, Jingqi Cheng, Biqi Liu, Chaoxin Man, Ling Guo, Xinyan Yang, Qianyu Zhao, Yujun Jiang.  (2024)  Label-free and sensitive fluorescent detection of Escherichia coli O157: H7 in milk based on cascade strand displacement amplification and G-quadruplex-thioflavin T.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2024.110499]

82. Weiyi Lu, Bin Yang, Zihua Guo, Zhen Tian, Wenhui He, Tiancheng Yang.  (2024)  Machine learning-based fluorescence sensor array: Accurate discrimination, quantitative assay of phenothiazine drugs via versatile DNA probes.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.135330]

83. Fei Ding, Xiaomin Hang, Sen Tian, Wei Cao, Jingwen Wu, Li Wang.  (2025)  Nicking endonuclease-mediated primer exchange reaction for rapid and sensitive miRNA detection.  ANALYTICA CHIMICA ACTA,      [PMID:40187879] [10.1016/j.aca.2025.343902]

84. Yutong Ye, Yongli Ji, Chunyan Ma, Jun Guo, Zhongxiu Chen, Yi Liu, Hongli Chen.  (2025)  Niobium carbide MXenzyme for targeting disaggregation of human insulin fibrils and anti-inflammation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40158572] [10.1016/j.ijbiomac.2025.142542]

85. Ze Chen, Zuyao Fu, Xiaoyu Du, Jing Xie, Zhaoyang Ding.  (2024)  Novel aptamer fluorescence assays for malachite green and leucomalachite green detection.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111391]

86. Hao Liu, Zhiming Liu, Jiang Xiao, Xiaohui Liu, Hui Jiang, Xuemei Wang.  (2024)  Photo-induced Oriented Crystallization of Intracellular Nanocrystals Based on Phase Separation for Diagnostic Bioimaging and Analysis.  Advanced Healthcare Materials,      [PMID:38272459] [10.1002/adhm.202303248]

87. Chunhong Liu, Yexuan Wang, Xiaohan Dai, Ye Zhang, Yue Yang, Bin Jiang, Dongmei Li, Zhibiao Feng.  (2024)  Post-self-assemble of whey protein isolation nanofibrils and its contribution to the stability of pickering emulsion.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2024.109766]

88. Yi Hao, Jian Shang, Shuyan Liu, Xuemeng Tian, Xin Yao, Fengjun Liu, Ruizhen Zhu, Yue Wang, Ruixia Gao, Sicen Wang.  (2025)  Preparation of protein-resistant magnetic molecularly imprinted polymers as solid-phase extraction adsorbents via a one-stone-two-birds strategy for selective enrichment of tetracycline in milk.  TALANTA,      [PMID:39904252] [10.1016/j.talanta.2025.127678]

89. Qiang-Ming Li, Hui-Hui Han, Dan-Dan Zang, Xue-Qiang Zha, An Zhou, Feng-Yun Zhang, Jian-Ping Luo.  (2024)  Rapid Discovery of Aβ42 Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer’s Disease.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38362879] [10.1021/acs.jafc.3c08664]

90. Tai-Cheng Lu, Yi-Ting Lin, Wen-Biao Xiao, Qing-Zhen Qiu, Hui-Yun Tian, Yun Lei, Ai-Lin Liu.  (2024)  Reagent-free anti-fouling electrochemical immunosensor based on AL-BSA/AuNPs/PANI coating for the point-of-care detection of C-reactive protein in plasma and whole blood.  BIOSENSORS & BIOELECTRONICS,      [PMID:39146772] [10.1016/j.bios.2024.116667]

91. Shufen Wu, Changyan Dong, Meihui Zhang, Yi Cheng, Xiaobo Cao, Benxu Yang, Chao Li, Xin Peng.  (2024)  Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin.  Foods,  13  (10): (1573).  [PMID:38790873] [10.3390/foods13101573]

92. Longjiang Tian, Xinran You, Jingbo Liu, Yajuan Li, Shanglin Li, Xuemin Jin, Shugang Li, Fei Pan, Zhipeng Yu, Ting Zhang, Zhiyang Du.  (2024)  Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39644243] [10.1021/acs.jafc.4c08256]

93. Jiaqi Song, Liang Shao, Hongwen Yu, Caiting Meng, Guanying Li.  (2024)  Self-Assembly of Sulfate-Containing Peptides Sequesters VEGF for Inhibiting Cancer Cell Invasion.  BIOMACROMOLECULES,      [PMID:38584438] [10.1021/acs.biomac.4c00168]

94. Weiqiang Wang, Fengjiao Chu, Weifeng Zhang, Tingting Xiao, Jingjing Teng, Yan Wang, Bo He, Binghui Ge, Jiajia Gao, Honghua Ge.  (2024)  Silver Mineralized Protein Hydrogel with Intrinsic Cell Proliferation Promotion and Broad-Spectrum Antimicrobial Properties for Accelerated Infected Wound Healing.  Advanced Healthcare Materials,      [PMID:38364079] [10.1002/adhm.202400047]

95. Junjie Wang, Xiang Guo, Xingchun Jiang, Xueyan Hu, Cui Wang, Yang Han, Hao Wu.  (2024)  The effect of glass container surface silanol density on monoclonal antibody formulation stability after application of mechanical shock.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:39743159] [10.1016/j.ijpharm.2024.125152]

96. Yanan Zhao, Yan Liang, Xinxin Wang, Xinyu Zu, Hua Wang.  (2024)  Utilization of peanut protein isolate amyloid-like fibers as stabilizers for high internal phase Pickering emulsions.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2024.118414]

97. Xinyue Wang, Junjie Wang, Yang Han, Xingchun Jiang, Sixian Cao, Dongze Xu, Tiancheng Xiong, Xiang Guo, Cui Wang, Sha Guo, Hongying Song, Ting Dong, Le Zhang, Zhenming An, Jun Liu, Jing Han, Hao Wu.  (2024)  Utilizing a hydrophobic primary container surface to reduce the formation of subvisible particles in monoclonal antibody solution caused by fluid shear.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:39293723] [10.1016/j.ejpb.2024.114502]

98. Xinmiao Xu, Yi Zhang, Yong Chen, Yu Liu.  (2024)  Vapor-Driven Crosslinked Hydroxypropyl-β-Cyclodextrin Electrospun Nanofibrous Membranes for Ultrafast Dye Removal.  Chemistry-Switzerland,  6  (4): (506-516).  [PMID:] [10.3390/chemistry6040029]

99. Tiange Fan, Xiuyun Cao, Chao Wang, Xu Shao, Xin Wang, Ping Guan, Xiaoling Hu.  (2024)  Vitamin C derived carbon dots: inhibiting amyloid aggregation and scavenging reactive oxygen species.  NEW JOURNAL OF CHEMISTRY,      [PMID:] [10.1039/D4NJ03688C]

100. Kang Wei, Wu Zhiyue, Huang Xinzhi, Qi Hongbin, Wu Jiaxuan, Wang Jiahui, Li Jing, Wu Sijin, Kang Byung-Ho, Li Bo, Ma Juncai, Xue Chuang.  (2025)  Time-dependent catalytic activity in aging condensates.  Nature Communications,  16  (1): (1-16).  [PMID:40730570] [10.1038/s41467-025-62074-5]

101. Ding Zhao, Yihan Li, Lei Xiang, Qimanguli Saiding, Zhiqi Lin, Zhengwei Cai, Juan Wang, Wenguo Cui.  (2025)  Cell Shock Absorption via Stress Relaxation Hydrogel Microspheres for Alleviating Endoplasmic Reticulum Stress in Chondrocytes.  Research,      [PMID:40678150] [10.34133/research.0777]

102. Huiying Xu, Yujing Zhang, Lihua Shen, Shu Yu, Changqing Li, Xianfei Zeng, Qin Liu, Bang-Ce Ye.  (2025)  Sensitive Detection of Exosomal Biomarkers via a Drop-Shaped Porous Microfluidic Chip for Potential Diagnosis of Alzheimer’s Disease.  ANALYTICAL CHEMISTRY,      [PMID:40641259] [10.1021/acs.analchem.5c02003]

103. Ji Yongli, Yang Caoyu, Ye Yutong, Zhang Yin, Zhao Tingting, Kong Shuyue, Chen Hongli, Liu Pai, Zhao Zelong, Li Yilong, Li Jing, Ma Ruixiao, Ban Zhiyong, Yuan Kuo, Tang Zhiyong, Liu Yi, Zhao Meiting, Guo Jun.  (2025)  Disassembly of chiral hydrogen-bonded frameworks into single-unit organometallic helices for enantioselective amyloid inhibition.  Nature Communications,  16  (1): (1-15).  [PMID:40866394] [10.1038/s41467-025-63459-2]

104. Yujing Lu, Yicheng Guo, Jiarui Jin, Jiahao Xie, Xiufang Dong, Hang Qi.  (2025)  Preparation of pH-responsive hydrogel microspheres based on fibrillated soy protein isolate and sodium alginate and investigation of polyphenol release behavior from Ascophyllum nodosum.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.111861]

105. Peng Chen, Lancheng Wang, Dandan Xue, Mingjie Xu, Chi Hu.  (2025)  Post-SELEX optimisation of split aptamers via a supramolecular anchoring strategy.  SUPRAMOLECULAR CHEMISTRY,      [PMID:] [10.1080/10610278.2025.2548812]

106. Xiaoshuai Wang, Xiangyu Liang, Yilin Wang, Xiaoqian Li, Yan Zhang, Jing Wang, Zejian Xu, Xiaonan Sui.  (2025)  Regulating the structure and hydrogel properties of soy protein amyloid fibrils through metal ion-mediated alkaline dialysis strategy.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.112050]

107. Yarong Zhang, Hongyan Ma, Zhenyao Gao, Miao Li, Fan Yang, Lingbo Sun, Yuecheng Zhang.  (2025)  Label-Free and Ultrasensitive APE1 Detection Based on Hybridization Chain Reaction Combined with G-Quadruplex.  Biomolecules,  15  (9): (1275).  [PMID:41008582] [10.3390/biom15091275]

108. Jiaojiao Yang, Lijun Feng, Jing Liu, Sheng Li, Na Li, Xinfeng Zhang.  (2023)  DNA-mediated charge neutralization of AuNPs for colorimetric sensing of Hg2+ in environmental waters and cosmetics.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.134697]

109. Daikun Li, Jun Zhang, Wei Zhan, Guiyuan Cai, LiPin Li, Wei Zuo, Qinyu Wang, Yu Tian.  (2022)  Aminated polystyrene-polymaleic(anhydride) hollow microsphere membrane for fast and efficient dyes and oils filtration from water.  Journal of Materials Chemistry A,  10  (26): (13936-13945).  [PMID:] [10.1039/D2TA02218D]

110. Min Hou, Liyang Shi, Yancen Zhou, Jiao Wang, Jiali Jiang, Jianhui Jiang, Jianjun He.  (2021)  Expanding the codes: The development of density-encoded hydrogel microcarriers for suspension arrays.  BIOSENSORS & BIOELECTRONICS,      [PMID:33744669] [10.1016/j.bios.2021.113133]

111. Hao Liu, Zhiming Liu, Hao Zhang, Ke Huang, Xiaohui Liu, Hui Jiang, Xuemei Wang.  (2024)  Mineralized aggregates based on native protein phase transition for non-destructive diagnosis of seborrheic skin by surface-enhanced Raman spectroscopy.  Materials Horizons,      [PMID:39086255] [10.1039/D4MH00613E]

112. Yuewen Zhai, Fan Gao, Shihao Shi, Qifeng Zhong, Jinnan Zhang, Ji Fang, Fang He, Yanqin Zhang, Yu Li, Fei Liu, Bing Xue, Yueqing Gu, Siwen Li.  (2025)  Noninvasive Optogenetics Realized by iPSC-Derived Tentacled Carrier in Alzheimer's Disease Treatment.  ADVANCED MATERIALS,      [PMID:40434197] [10.1002/adma.202419768]

113. Xue Lu, Yuanyuan Liu, Yaoyao Wei, Changle Meng, Jie Zhou, Yang Zhang, Nuan Dong, Hua Zhang, Wen Chen, Han Zhang.  (2025)  Black phosphorus quantum dots nanocomposite for fluorescence detection and modulation of β-amyloid protein.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.137011]

114. Shuyu Zhu, Shiying Zhou, Liyuan Deng, Jiangbo Dong, Tao Gu, Xinyu He, Liang Jin, Changjun Hou, Danqun Huo.  (2025)  Target inhibition of rolling circle amplification generates G43 long nanowires for reverse signaling determination of alkaline phosphatase.  ANALYTICA CHIMICA ACTA,      [PMID:40382111] [10.1016/j.aca.2025.344077]

115. Xinyu Jiang, Yongliang Ma, Feng Gao, Yali Yu.  (2025)  Formation of tiger nut protein fibrils through self-assembly and different nuclei-induced pathways: Focus on structure and core peptide region.  FOOD CHEMISTRY,      [PMID:40311576] [10.1016/j.foodchem.2025.144557]

116. Jianhua Yuan, Ying Wu, Yucong Shi, Lei Zhou, Yanjun Zhang, Chengmei Liu, Junzhen Zhong.  (2025)  Characterization and mechanism of formation of fibrous and worm-like β-lactoglobulin self-assemblies.  JOURNAL OF FOOD SCIENCE,  90  (3): (e70154).  [PMID:40145620] [10.1111/1750-3841.70154]

117. Yinqiang Xia, Jin Zhao, Zheying Gao, Yifei Ruan, Siqi Wang, Liangbin Hu, Tianli Yue.  (2025)  Fabrication of cost-effective antifouling sensors with conjugation of hyaluronic acid and phase-transited BSA for the rapid detection of gentamicin.  TALANTA,      [PMID:40378761] [10.1016/j.talanta.2025.128308]

118. Jian Li, Tingting Wang, Xun Zhang, Xinhui Su, Nian Liu.  (2025)  Chalcogenapyrylium-engineered D-π-A probe for enhanced optoacoustic imaging of amyloid-β plaques.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.138086]

119. Xirui Long, Yuanyuan He, Ao Wang, Xiao Wang, Ao Zhen, Linxi Wu, Lin Yang, Feng Luo, Jiehua Li, Zhen Li, Hong Tan.  (2025)  Lysozyme Fiber-Inspired Versatile Supramolecular Hydrogel Against Drug-Resistant Pathogens and Biofilm Formation.  Advanced Healthcare Materials,      [PMID:40457631] [10.1002/adhm.202500687]

120. Meng You, Xinxin Zhang, Yanli Zhang, Jialu Sun, Qiuyan Sha, Mengdie Wang, Huaiyue Zhang, Di Shen, Yunlong Zhang, Ning Wang, Ying Liu, Yu Liu.  (2025)  Impact of mechanical stress on human transthyretin protein amyloid formation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40527379] [10.1016/j.ijbiomac.2025.145291]

121. Xiquan Li, Jun Yang, Liting Feng, Hao Guo, Xiaochen Liu, Xiuling Zhang, Wentao Zhang.  (2025)  Acidic-heating induced protein fibrils derived from perilla seed residues: spotlight on assembly behavior, conformational changes and structure-function relationships.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.111709]

122. Mu Zhenlong, Chen Yang, Hu Yunfeng, Wang Hui, Li Jin.  (2025)  Tailored brain metastatic tumor cells-derived apoptotic bodies ameliorate Alzheimer’s disease by promoting microglia efferocytosis and neuroinflammation mitigation.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-26).  [PMID:41068796] [10.1186/s12951-025-03750-y]

123. Yujun Wu, Lingyu Qiu, Xiatong Ou, Jingjing Tao, Min Zheng, Yan Huang, Shumeng Bai.  (2025)  Injectable Silk Fibroin-Based Hydrogels with Ultrafast In Situ Gelation via an Unfolding-Aggregating Strategy for Osteoarthritis Treatment.  BIOMACROMOLECULES,      [PMID:41043411] [10.1021/acs.biomac.5c01002]

124. Bingjie Hu, Yee Ying Lee, Chin−Ping Tan, Weihao Chen, Yong Wang, Chaoying Qiu.  (2025)  Modulating mechanisms of pea protein fibrils on the interfacial distribution of diacylglycerol and structural rigidity of emulsion gel.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.112152]

125. Kexin Li, Xiaojing Zhang, Liqun Xu, Kun Xu, Xi Rao, Selvakumar Murugesan, Valentim A. R. Barão, Peng Yang, En-Tang Kang.  (2025)  Amyloid-like Protein-Metal Sulfide Nanocoatings for Synergistic Photothermal and Antibacterial Implant Surface Protection.  ACS Nano,      [PMID:41090291] [10.1021/acsnano.5c14509]

126. Meiyuan Han, Zhikang Su, Jiarong Mi, Pan Qi, Zhongchen Xu, Jun Zhang, Jiangfeng Qian, Cunlan Guo.  (2025)  Humidity-Responsive dBSA-MoS2 Nanocomposite Film Assembled via Liquid–Liquid Interface for Simulating Artificial Synaptic Behavior.  ACS Applied Electronic Materials,      [PMID:] [10.1021/acsaelm.5c01713]

127. Wen-Qian Lian, Zi-Yang Fan, Sheng He, Shu-Ling Yang, Gui-Chuan Wei, Rui-Ying Bao, Wei Yang.  (2025)  Facile Exfoliation of Silk Nanofibrils Enabled by Hydrogen Bond Network Reconfiguration in Deep Eutectic Solvent/Water Systems.  BIOMACROMOLECULES,      [PMID:41074831] [10.1021/acs.biomac.5c01371]

128. Xueyin Hu, Wei Cheng, Jun Che, Yuanfang Chen, Yue Shang, Cong Gao, Changfen Bi, Saijun Fan, Shuqin Li, Luntao Liu.  (2025)  Multistage Biobarrier-Adaptive Peptide Radiosensitizer with Low-Dose X-ray Augments Glioblastoma Radiotherapy via Destabilizing Lysosomal Homeostasis.  ACS Nano,      [PMID:41350241] [10.1021/acsnano.5c15001]

129. Liang Zhang, Puxuan Zhang, Haocheng Tong, Yue Zhao, Tengfei Yu, Guanchen Liu, Donghong Liu.  (2025)  The Reconstruction of Sesame Protein-Derived Amyloid Fibrils Alleviates the Gastric Digestion Instability of β-Carotene Nanoparticles.  Nanomaterials,  15  (23): (1829).  [PMID:41369499] [10.3390/nano15231829]

130. Hongyu Ye, Yanyan Zhen, Shuyu Chen, Yuxian Lin, Xiaomin Xu, Yingcong Yu, Xianfeng Huang, Yajing Wang, Jing Xie.  (2025)  Elastic cationic liposomal nanogels: a novel platform for topical nicotinamide mononucleotide delivery.  JOURNAL OF LIPOSOME RESEARCH,      [PMID:41383026] [10.1080/08982104.2025.2584982]

131. Gongshuai Song, Taijiao Xiang, Haina Hou, Danli Wang, Tinglan Yuan, Ling Li, Jianchang Jin, Ziyuan Wang, Fuping Zheng, Mengna Zhang, Jinyan Gong.  (2025)  Cold plasma induced amyloid β-lactoglobulin fibrils-fucoidan self-assembled complexes for lycopene delivery: Structural characterization, emulsion stability, and in vitro release behaviour.  FOOD CHEMISTRY,      [PMID:41197318] [10.1016/j.foodchem.2025.146846]

132. Yangyang Guo, Xingru Yan, Jie Pang, Bo Liu, Yihua Bai, Di Wu, Yukun Song, Mingqian Tan, Wentao Su.  (2025)  Konjac glucomannan-based emulsion films with lysozyme-amyloid fibrils-chitosan complexes as dual-function antimicrobial emulsifiers for salmon preservation.  FOOD CHEMISTRY,      [PMID:41506230] [10.1016/j.foodchem.2025.147823]

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