Thiolutin - ≥95% , CAS No.87-11-6

Name: Thiolutin - ≥95% , CAS No.87-11-6
Brand: Aladdin Scientific
SKU: T102393
Availability: InStock

CAS: 87-11-6 Cat. No.: T102393 Formule: C₈H₈N₂O₂S₂ Poids moléculaire: 228.29 Numéro CE: 635-840-2 PubChem CID: 6870

1 Citations COA

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Thiolutin - ≥95% CAS No(87-11-6) by Aladdin Scientific

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DISPONIBLE À COMMANDE

QUALITÉ & PURETÉ ≥95%

Synonyms

AS-72926 | 3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole | 1,2-DITHIOLO(4,3-B)PYRROL-5(4H)-ONE, 6-ACETAMIDO-4-METHYL- | NSC 3927 | 1, 6-acetamido-4-methyl- | 6-Acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one | HY-N6712 | BRN 0209485 | N-(4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Fiche de spécifications

Vue d’ensemble Spécifications Noms et identifiants Documentation Données avancées Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Citations of This Product Calculateurs de solution Avis Foire aux questions

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Pourquoi cette qualité

≥95% pour les flux de travail chromatographiques et analytiques sensibles nécessitant une interférence de ligne de base minimale.

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Stockage & expédition

Store at -20°C Expédition Ice chest + Ice pads. Consultez le COA spécifique au lot pour les spécifications exactes.

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Documents qualité

SDS, COA, fiche technique et fiche de spécifications disponibles au téléchargement. COA spécifique au lot accessible via la recherche par numéro de lot.

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Preuve documentaire

Cité dans 1 publications à comité de lecture couvrant la chromatographie, la synthèse organique et les réactions de couplage croisé.

Vue d’ensemble

Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. The compound has been shown to inhibit transcription in Saccharomyces cerevisiae and mRNA degradation. Thiolutin inhibits the adhesion of endothelial cells, including adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin, and restricts tumor cell-induced angiogenesis. Studies have reported that Thiolutin is an effective inducer of HSP 27 (heat shock protein 27; Hsp27) phosphorylation. Research shows that in the presence of Thiolutin, the interaction between Hsp27 and nestin is disrupted, which results in the breakdown of nestin filaments.
An RNA polymerase inhibitor and suppressor of tumor cell-induced angiogenesis

Spécifications

Synonymes

Spécifications et pureté

≥95%

Mécanismes biochimiques et physiologiques

Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC 50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureté

≥95%

Noms et identifiants

Pubchem Sid

488180184

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488180184

Sourires canoniques

CC(=O)NC1=C2C(=CSS2)N(C1=O)C

IUPAC Name

N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide

InChIKey

MHMRAFONCSQAIA-UHFFFAOYSA-N

INCHI

1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)

Isomères SMILES

CC(=O)NC1=C2C(=CSS2)N(C1=O)C

WGK Allemagne

RTECS

JP1355000

PubChem CID

6870

Numéro ONU

2811

Poids moléculaire

228.29

Documentation

📋 Fiche de données de sécurité (FDS)

Document complet couvrant les dangers, la manipulation, le stockage et la conformité réglementaire.

<<<<<<< HEAD Télécharger la SDS → ======= Télécharger la SDS → >>>>>>> release248-p3

✅ Certificat d'analyse (COA)

Données qualité spécifiques au lot. Saisissez votre numéro de lot pour récupérer le COA exact.

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📊 Fiche technique

Résumé de référence rapide des spécifications et applications du produit.

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🔬 Fiche de spécifications

Attributs de qualité complets et critères d'acceptation pour cette qualité.

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Données avancées

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Classe Organonitrogen compounds
    - Subclass N-arylamides

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Classe	Organonitrogen compounds
Subclass	N-arylamides
Intermediate Tree Nodes	Not available
Direct Parent	N-acetylarylamines
Alternative Parents	N-methylpyrroles Heteroaromatic compounds Acetamides 1,2-dithioles Secondary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-acetylarylamine - N-methylpyrrole - Substituted pyrrole - Pyrrole - 1,2-dithiole - Dithiole - Acetamide - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Lactam - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Carbonyl group - Organopnictogen compound - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-acetylarylamines. These are acetamides where one or more amide hydrogens is substituted by an aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Structure 3D

Cibles associées (humaines)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Article
D2318550	Certificate of Analysis	Mar 15, 2023	T102393
D2318588	Certificate of Analysis	Mar 15, 2023	T102393
D2318589	Certificate of Analysis	Mar 15, 2023	T102393
D2318591	Certificate of Analysis	Mar 15, 2023	T102393
E1528141	Certificate of Analysis	Feb 07, 2023	T102393

Solubilité	Soluble in DMSO (5 mg/ml), and water (210 mg/L).
Sensibilité	Light sensitive
Poids moléculaire	228.300 g/mol
XLogP3	-0.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	228.003 Da
Monoisotopic Mass	228.003 Da
Topological Polar Surface Area	100.000 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	387.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Thiolutin - ≥95% , CAS No.87-11-6

Stockage & expédition

Documents qualité

Preuve documentaire

Vue d’ensemble

Spécifications

Documentation

📋 Fiche de données de sécurité (FDS)

✅ Certificat d'analyse (COA)

📊 Fiche technique

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Données avancées

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Avis des clients

Foire aux questions

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