Tolfenamic Acid - Moligand™, 10mM in DMSO , Inhibitor of AKR1C3, CAS No.13710-19-5, Inhibitor of AKR1C3

CAS: 13710-19-5 Cat. No.: T407845 Formule: C₁₄H₁₂ClNO₂ Poids moléculaire: 261.7 Numéro CE: 237-264-3 PubChem CID: 610479

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Tolfenamic Acid is aCOX-2inhibitor withIC50of 0.2 μM.
In vitro

In vivo

Cell Data

cell lines：RF/MT-2 strains

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonymes

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of AKR1C3

Noms et identifiants

• Isomères SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O
• WGK Allemagne: 3
• RTECS: CB2687500
• PubChem CID: 610479
• Poids moléculaire: 261.7
• Reaxy-Rn: 657821

Cibles associées (humaines)

TTR Tclin Transthyretin (1 Activities)

Discover Target: TTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)

Discover Target: AKR1C3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 62 mg/mL (186.25 mM)
• Point de fusion (°C): 209-214°C

Références

1. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang.  (2020)  A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2020.1740178]

2. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu.  (2019)  Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use.  CRYSTENGCOMM,  21  (35): (5284-5291).  [PMID:] [10.1039/C9CE00781D]

3. Xue Shu-Wen, Li Jing, Xu Li.  (2017)  Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (12): (3103-3113).  [PMID:28224244] [10.1007/s00216-017-0251-8]

4. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo.  (2015)  Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  182  (15): (2585-2591).  [PMID:] [10.1007/s00604-015-1638-x]