UK-5099 - Moligand™, ≥98% , Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2, CAS No.56396-35-1, Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2

CAS: 56396-35-1 Cat. No.: U126881 Formule: C₁₈H₁₂N₂O₂ Poids moléculaire: 288.3 Numéro CE: 693-266-8 PubChem CID: 6438504

QUALITÉ & PURETÉ Moligand™, ≥98%

Synonyms

( E)-2-Cyano-3-(1-phényl-1H-indol-3-yl)acide acrylique | PF-1005023 | (E)-2-Cyano-3-(1-phényl-1H-indol-3-yl)-2-propénoïque | (E)-2-Cyano-3-(1-phényl-1H-indol-3-yl)acide acrylique | Inhibiteur du transporteur de pyruvate mitochondrial | ( E)-2-Cyano-3-(1-p

Storage

Conserver à -20°C

Shipped In

Glacière + blocs de glace

Vue d’ensemble

application：

UK-5099 a été utilisé

comme bloqueur du pyruvate mitochondrial pour réduire le transport du pyruvate dans les mitochondries dans le milieu Roswell park memorial institute (RPMI) 1640 pour la culture de lignées cellulaires du cancer de la prostate

dans un stock de diméthyl sulfoxyde (DMSO), afin d'étudier l'effet de l'inhibition du transport du pyruvate dans les mitochondries sur les réponses pro-inflammatoires des macrophages activés par le lipopolysaccharide

en traitement topique afin d'étudier son effet sur l'induction du cycle pilaire chez les souris expérimentales.

Description du produit

UK-5099 (PF-1005023) est un puissant inhibiteur du transporteur de pyruvate mitochondrial (MPC). UK-5099 (PF-1005023) inhibe la consommation d'O2 dépendante du pyruvate avec une IC50 de 50 nM.

Spécifications

Synonymes

( E)-2-Cyano-3-(1-phényl-1H-indol-3-yl)acide acrylique | PF-1005023 | (E)-2-Cyano-3-(1-phényl-1H-indol-3-yl)-2-propénoïque | (E)-2-Cyano-3-(1-phényl-1H-indol-3-yl)acide acrylique | Inhibiteur du transporteur de pyruvate mitochondrial | ( E)-2-Cyano-3-(1-p

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

Inhibiteur des transporteurs de monocarboxylate (MCT) de la membrane plasmique et du transporteur de pyruvate mitochondrial (MPC). UK-5099 induit la production de lactate.

Informations juridiques

Vendu uniquement à des fins de recherche

Conditions de stockage de stockage

Conserver à -20°C

Expédié en

Glacière + blocs de glace

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2

Pureté

≥98%

Noms et identifiants

Pubchem Sid

488195788

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488195788

Sourires canoniques

C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O

IUPAC Name

(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid

InChIKey

BIZNHCWFGNKBBZ-JLHYYAGUSA-N

INCHI

1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+

Isomères SMILES

C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)/C=C(\C#N)/C(=O)O

WGK Allemagne

3

PubChem CID

6438504

Poids moléculaire

288.3

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyrroles
      • Subclass Substituted pyrroles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyrroles
• Subclass: Substituted pyrroles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrroles
• Alternative Parents: Indoles Benzene and substituted derivatives Heteroaromatic compounds Nitriles Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1-phenylpyrrole - Indole - Indole or derivatives - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Azacycle - Nitrile - Carbonitrile - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Cyanide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpyrroles. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

MPC2 Tbio Mitochondrial pyruvate carrier 2 (0 Activities)

Discover Target: MPC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPC1 Tbio Mitochondrial pyruvate carrier 1 (0 Activities)

Discover Target: MPC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)

Discover Target: SLC16A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 28.83, Max Conc. mM: 100
• Sensibilité: heat sensitive
• Poids moléculaire: 288.300 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 288.09 Da
• Monoisotopic Mass: 288.09 Da
• Topological Polar Surface Area: 66.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 498.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 56396-35-1, the molecular formula is C18H12N2O2, and the molecular weight is 288.3 g/mol. InChIKey BIZNHCWFGNKBBZ-JLHYYAGUSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.