UNC6852 - ≥99% , CAS No.2688842-08-0

CAS: 2688842-08-0 Cat. No.: U651045 Formule: C₄₃H₄₈N₁₀O₆S Poids moléculaire: 832.97

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Vue d’ensemble

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED

In Vitro

UNC6852 mediates PRC2 degradation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells. UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment. UNC6852 selectively degrades EED and EZH2. UNC6852 reduces H3K27me3 levels and DLBCL cell proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: DLBCL Cells Concentration: 3 μM Incubation Time: 0 -10 days Result: Exhibited anti-proliferative effects. Western Blot AnalysisCell Line: HeLa Cells Concentration: 10 μM Incubation Time: 1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours Result: Resulted in a decrease in the levels of both EED and EZH2.

Form:Solid

IC50& Target:IC50: 247 nM (EED)

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

• Poids moléculaire: 832.97

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (120.05 mM; Need ultrasonic)