Verlukast - Moligand™, ≥98% , Antagonist of CysLT 1 receptor;Inhibitor of OATP2B1, CAS No.120443-16-5, Antagonist of CysLT 1 receptor;Inhibitor of OATP2B1

CAS: 120443-16-5 Cat. No.: V127296 Formule: C₂₆H₂₇ClN₂O₃S₂ Poids moléculaire: 515.09

QUALITÉ & PURETÉ Moligand™, ≥98%

Synonyms

3-(((.ALPHA.R)-M-((E)-2-(7-CHLORO-2-QUINOLYL)VINYL)-.ALPHA.-((2-(DIMETHYLCARBAMOYL)ETHYL)THIO)BENZYL)THIO)PROPIONIC ACID|3-[{3-[2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid|Fenspiride hydrochloride (USAN)|VERLUKAST [INN]|Ellsyl (TN)|3-(((alphaR)-m-((E)-2-(7-Chloro-2-quinolyl)vinyl)-alpha-((2-(dimethylcarbamoyl)ethyl)thio)benzyl)thio)propionic acid|Ashitetra; Duxamintic|Propanoic acid, 3-(((3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)-, (R-(E))-|MK 0679|Propanoicacid,3-[[(R)-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-|Verlukast (USAN/INN)|VERLUKAST [USAN]|L-668019|Propanoic acid, 3-[[(R)-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-|3-[[(R)-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid|Verlukastum [INN-Latin]|VERLUKAST|MK679|MK-679|L 668019|L-668,019|L 668,019|(R,E)-3-(((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoic acid|MK-0679|3-[(R)-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid|MK 679|Verlukast [USAN:INN]

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Product Application:

A receptor antagonist for the treatment of respiratory diseases.

Spécifications

Synonymes

3-(((.ALPHA.R)-M-((E)-2-(7-CHLORO-2-QUINOLYL)VINYL)-.ALPHA.-((2-(DIMETHYLCARBAMOYL)ETHYL)THIO)BENZYL)THIO)PROPIONIC ACID | 3-[{3-[2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid | Fenspiride hydrochloride (USAN) | VERLUKAST [INN] | Ellsyl (TN) | 3-(((alphaR)-m-((E)-2-(7-Chloro-2 Afficher plus

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

Verlukast(MK-679; L 668019) is a receptor antagonist for the treatment of respiratory diseases.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST, INHIBITOR

Mécanisme d'action

Antagonist of CysLT 1 receptor;Inhibitor of OATP2B1

Pureté

≥98%

Noms et identifiants

Pubchem Sid

504764271

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504764271

Sourires canoniques

CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O

IUPAC Name

3-[(R)-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid

InChIKey

AXUZQJFHDNNPFG-LHAVAQOQSA-N

INCHI

1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+/t26-/m1/s1

Isomères SMILES

CN(C)C(=O)CCS[C@@H](C1=CC=CC(=C1)/C=C/C2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O

Poids moléculaire

515.09

Reaxy-Rn

24674053

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24674053&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Haloquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Haloquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Chloroquinolines
• Alternative Parents: Styrenes Aryl chlorides Pyridines and derivatives Tertiary carboxylic acid amides Dithioacetals Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Carboxylic acids Dialkylthioethers Monocarboxylic acids and derivatives Organonitrogen compounds Organochlorides Hydrocarbon derivatives Carbonyl compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Chloroquinoline - Styrene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyridine - Benzenoid - Heteroaromatic compound - Thioacetal - Tertiary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Dialkylthioether - Sulfenyl compound - Thioether - Organohalogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Carbonyl group - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as chloroquinolines. These are compounds containing a quinoline moiety, which carries one or more chlorine atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (1 Activities)

Discover Target: SLCO2B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (3 Activities)

Discover Target: CYSLTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)

Discover Target: CYSLTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Abcc1 Multidrug resistance-associated protein 1 (42 Activities)

Discover Target: Abcc1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cavia porcellus (23802 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), THF (Slightly, Sonicate)
• Point de fusion (°C): 57-62°C
• Poids moléculaire: 515.100 g/mol
• XLogP3: 5.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 514.115 Da
• Monoisotopic Mass: 514.115 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 693.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1