Verteporfin - Moligand™, ≥97% , CAS No.129497-78-5

CAS: 129497-78-5 Cat. No.: V129759 Formule: C₄₁H₄₂N₄O₈ Poids moléculaire: 718.79 Numéro CE: 893-418-5

GRADE & PURITY Moligand™, ≥97%

Synonyms

Visudyne | BPD-MA | CL 318952

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis[1]. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation.

Specifications

Synonymes

Visudyne | BPD-MA | CL 318952

Spécifications et pureté

Moligand™, ≥97%

Mécanismes biochimiques et physiologiques

Vitepofin is a photosensitizer for photodynamic therapy, which can be used to eliminate abnormal blood vessels in eyes related to macular degeneration and other diseases. Vitipofen can accumulate in abnormal blood vessels. When stimulated by non-thermal r

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureté

≥97%

Noms et identifiants

Pubchem Sid

488195426

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488195426

Isomères SMILES

CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C

WGK Allemagne

3

Poids moléculaire

718.79

Reaxy-Rn

14615024

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14615024&ln=

Propriétés chimiques et physiques

• Solubilité: DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Sensibilité: Light sensitive
• Poids moléculaire: 718.800 g/mol
• XLogP3: 4.900
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 12
• Exact Mass: 718.3 Da
• Monoisotopic Mass: 718.3 Da
• Topological Polar Surface Area: 174.000 Ų
• Heavy Atom Count: 53
• Formal Charge: 0
• Complexity: 1500.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1