2,4′-Dihydroxybenzophenone - Moligand™, 10 mM in DMSO , CAS No.131-56-6

CAS: 131-56-6 Cat. No.: D1500499 分子式: C₁₃H₁₀O₃ 分子量: 214.22 Beilstein Registry Number: 1311566 EC番号: 205-029-4

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4 . 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88 , p-IRAK4, and NF-κB . 2,4′-Dihydroxybenzophenone is also a UV absorber .

Specifications

仕様と純度

Moligand™, 10 mM in DMSO

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

名前と識別子

• 異性体SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)O)O
• WGKドイツ: 2
• RTECS: DJ0700000
• 分子量: 214.22
• Beilstein: 1311566
• Reaxy-Rn: 1311566
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1311566&ln=

化学的性質と物理的性質

• 引火点（°F）: 257°F
• 引火点（°C）: 125℃
• 沸点（°C）: 194°/1mm
• 融点（°C）: 144°C

参考文献

1. Guokai Cui, Chengyu Ren, Ruina Zhang, Xing Li, Zhenzhen Yang, Lei Zhang, Quanli Ke, Ying Zhou, Hanfeng Lu, Sheng Dai.  (2025)  Cuprous ionic liquid engineering combined with preorganized hydrogen-bond donors for enhanced carbon monoxide capture.  AICHE JOURNAL,      [PMID:] [10.1002/aic.70030]

2. Huiyu He, Rui Wang, Rongbin Nie, Nan Dong.  (2025)  An environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid-phase dispersion extraction combined with HPLC-MS/MS for multiple analysis of pharmaceuticals and personal care products in aquatic organisms.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115146]

3. Man-Man Wang, Zi-Ling Li, Han Wu, Ke-Yan Chen, Fan Guo, Gui-Fu Zuo, Yu He, Xue-Bo Yin.  (2023)  Self-assembled Fe3O4-NH2 @g-C3N4 composite for magnetic solid-phase extraction of benzophenones in sea water and lake water coupled with LC-MS/MS determination.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37844496] [10.1016/j.jhazmat.2023.132776]

4. Hao Lin, Shaowei Wang, Yunbing Tang, Zhiyan Hu, Xiaofang Chen, Huitao Li, Yang Zhu, Yiyan Wang, Yi Liu, Ren-shan Ge.  (2023)  Benzophenone-type ultraviolet filters inhibit human and rat placental 3β-hydroxysteroid dehydrogenases: Structure-activity relationship and in silico docking analysis.  TOXICOLOGY LETTERS,      [PMID:37217011] [10.1016/j.toxlet.2023.05.006]

5. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan.  (2022)  Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD.  MICROCHIMICA ACTA,  189  (12): (1-10).  [PMID:36416994] [10.1007/s00604-022-05572-3]

6. Wang Xueting, Chang Rui, Ji Zhongyin, Song Jinying, Yuan Fei, Zhang Shijuan.  (2022)  Improved Extraction and Detection Method for Bisphenols Using Stable Isotope Labeling Technique.  Food Analytical Methods,  16  (2): (281-292).  [PMID:] [10.1007/s12161-022-02413-0]

7. Yuanyuan Ren, Wei Deng, Wanyu Li, Hong Zhao.  (2022)  Graftable voltage stabilizer for enhancing insulation performance of crosslinked polyethylene.  JOURNAL OF APPLIED POLYMER SCIENCE,  139  (31): (e52703).  [PMID:] [10.1002/app.52703]

8. Xiaoyan Ouyang, Ruiyu Liang, Yuling Hu, Gongke Li, Changying Hu, Qisheng Zhong.  (2021)  Hollow tube covalent organic framework for syringe filter-based extraction of ultraviolet stabilizer in food contact materials.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:34537658] [10.1016/j.chroma.2021.462538]

9. Huazi Wang, Qinqin Xu, Jinglong Jiao, Hai Wu.  (2021)  A solidified floating organic drop-dispersive liquid–liquid microextraction based on in situ formed fatty acid-based deep eutectic solvents for the extraction of benzophenone-UV filters from water samples.  NEW JOURNAL OF CHEMISTRY,  45  (31): (14082-14090).  [PMID:] [10.1039/D1NJ01393A]

10. Jie Zhang, Dahai Zhang, Xiaogang Zhang.  (2020)  UV-0/HPC laminated coatings for protection of cellulosed-based cultural heritage against UV rays.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2020.109169]

11. Kaige Zhang, Shuangying Li, Yunhe Wang, Jing Fan, Guifen Zhu.  (2020)  Air-assisted liquid-liquid microextraction based on solidification of floating deep eutectic solvent for the analysis of ultraviolet filters in water samples by high performance liquid chromatography with the aid of response surface methodology.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31980262] [10.1016/j.chroma.2020.460876]

12. Ge Dandan, Zhong Guoqiong, Zhou Xiaojuan, Dai Enrui, Wang Ying.  (2019)  Elevated temperature-assisted surfactant-enhanced emulsification microextraction based on solidification of a floating organic drop for the determination of UV filters in water samples by high-performance liquid chromatography coupled to a diode array detector.  Journal of the Iranian Chemical Society,  17  (2): (499-506).  [PMID:] [10.1007/s13738-019-01785-1]

13. Wenqing Li, Rong Wang, Zilin Chen.  (2019)  Metal-organic framework-1210(zirconium/cuprum) modified magnetic nanoparticles for solid phase extraction of benzophenones in soil samples.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31378523] [10.1016/j.chroma.2019.460403]

14. Zheng Li, Haihua Feng, Yue Wang, Bingyu Shen, Ye Tian, Lin Wu, Qiaoling Zhang, Meiyu Jin, Guowen Liu.  (2018)  Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:30597292] [10.1016/j.intimp.2018.12.052]

15. Cheng Jie, Kong Xiaojian, Liu Shucheng, Che Dandan, Sun Zhiwei, Li Guoliang, Ping Meiling, Tang Jingpu, You Jinmao.  (2018)  Determination of Ultraviolet Filters in Domestic Wastewater by LC–MS Coupled with Polydopamine-Based Magnetic Solid-Phase Extraction and Isotope-Coded Derivatization.  CHROMATOGRAPHIA,  81  (12): (1673-1684).  [PMID:] [10.1007/s10337-018-3650-x]

16. Dandan Ge, Yi Zhang, Yixiu Dai, Shumin Yang.  (2017)  Air-assisted dispersive liquid–liquid microextraction based on a new hydrophobic deep eutectic solvent for the preconcentration of benzophenone-type UV filters from aqueous samples.  JOURNAL OF SEPARATION SCIENCE,  41  (7): (1635-1643).  [PMID:29282887] [10.1002/jssc.201701282]

17. Li Dong, Xiangdong Liu, Zhengrong Xiong, Dekun Sheng, Yan Zhou, Changhong Lin, Yuming Yang.  (2017)  Design of UV-absorbing PVDF membrane via surface-initiated AGET ATRP.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2017.11.135]

18. Huiqi Wang, Zheng Li, Wei Feng, Qiong Jia.  (2017)  Polymer monolith containing an embedded covalent organic framework for the effective enrichment of benzophenones.  NEW JOURNAL OF CHEMISTRY,  41  (21): (13043-13050).  [PMID:] [10.1039/C7NJ02512B]

19. Ye Tian, Zheng Li, Bingyu Shen, Lin Wu, Lu Han, Qiaoling Zhang, Haihua Feng.  (2017)  The protective effects of Shikonin on lipopolysaccharide/D-galactosamine-induced acute liver injury via inhibiting MAPK and NF-κB and activating Nrf2/HO-1 signaling pathways.  RSC Advances,  7  (55): (34846-34856).  [PMID:] [10.1039/C7RA03291A]

20. Dazhuang Xu, Meiying Liu, Hui Zou, Jianwen Tian, Hongye Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei.  (2017)  A new strategy for fabrication of water dispersible and biodegradable fluorescent organic nanoparticles with AIE and ESIPT characteristics and their utilization for bioimaging.  TALANTA,      [PMID:28738657] [10.1016/j.talanta.2017.07.010]

21. Ye Tian, Zheng Li, Bingyu Shen, Qiaoling Zhang, Haihua Feng.  (2017)  Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:28213269] [10.1016/j.intimp.2017.02.010]

22. Teng Ma, Zheng Li, Qian Niu, Yuanyuan Li, Weihong Zhou.  (2015)  Double dispersant-assisted ionic liquid dispersive liquid–liquid microextraction coupled with capillary electrophoresis for the determination of benzophenone-type ultraviolet filters in sunscreen cosmetic product.  ELECTROPHORESIS,  36  (20): (2530-2537).  [PMID:26105533] [10.1002/elps.201500004]

23. Ning Li, Quanfei Zhu, Yang Yang, Jianlin Huang, Xueping Dang, Huaixia Chen.  (2014)  A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner.  TALANTA,      [PMID:25476369] [10.1016/j.talanta.2014.10.038]

24. Xing Wang, Zhengze Wang, Siying Xiang, Minzhe Peng, Guangxian Li, Yajiang Huang.  (2024)  Developing polypropylene copolymer powder with a wide sintering window for laser powder bed fusion via extrusion and in-blend annealing.  Additive Manufacturing,      [PMID:] [10.1016/j.addma.2024.104188]

25. Ping He, Qian Zheng, Matin Naghizadeh, Guiqi Huang, Sheying Dong.  (2024)  Efficient and recycled magnetic self-stirring hollow fiber-solid/liquid phase system: An extraction and removal technique for personal care pollutants.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2024.124002]

26. Sheng Yan, Yunren Qiu.  (2024)  Improving Hemocompatibility of Polysulfone Membrane by UV-Assisted Grafting of Sulfonated Chitosan.  Polymers,  16  (11): (1555).  [PMID:38891507] [10.3390/polym16111555]

27. Xing Wang, Siying Xiang, Zhengze Wang, Minzhe Peng, Guangxian Li, Yajiang Huang.  (2024)  Unveiling the Multiplicity of Silica Nanoparticles in Improving the Laser Powder Bed Fusion Processability of Polypropylene Copolymer.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c03966]

28. Yangcheng Liu, Baoli Xu, Shengxue Wang, Qilin Liu, Zheng Xiang, Wanwei Jiang, Yang Wang.  (2025)  Constructing rice grain–dotted accordion-like TB–COF@NH₂–MXene to promote the simultaneous efficient elimination and sensitive detection of benzophenones.  FOOD CHEMISTRY,      [PMID:41475205] [10.1016/j.foodchem.2025.147715]