2-PMPA - ≥98%(HPLC) , CAS No.173039-10-6

CAS: 173039-10-6 Cat. No.: P167889 分子式: C₆H₁₁O₇P 分子量: 226.12 EC番号: 998-881-8 PubChem CID: 10130754

GRADE & PURITY ≥98%(HPLC)

Synonyms

HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

同義語

HMS3412K10 | HMS3676K10 | HY-100788 | 2-PMPA, >=98% (HPLC) | PMPA(NAALADaseinhibitor) | Pentanedioic acid, 2-(phosphonomethyl)- | UNII-XH88WJG9LJ | AKOS016004257 | HMS3749M13 | HMS3267D10 | (R,S)-2-phosphonomethylpentanedioic acid | YGA03910 | SCHEMBL3831

仕様と純度

≥98%(HPLC)

生化学的・生理学的メカニズム

2-PMPA 是一种有效的（IC50 ~ 1 nM）选择性谷氨酸羧肽酶 II（GCPII）抑制剂，也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I（NAALADase I）、NAAG 肽酶或前列腺素-特异性膜抗原（PSMA）。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍，并防止梭曼诱导的神经病理学。 2-PMPA 是谷氨酸羧肽酶 II（GCPII）的有效选择性抑制剂。 2-（膦酰基甲基）戊二酸（2-PMPA）阻断由低单位剂量的可卡因维持的静

保管条件

Store at -20°C,Argon charged

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%(HPLC)

名前と識別子

• パブケム・シド: 504765270
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504765270
• カノニカル・スマイル: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
• IUPAC Name: 2-(phosphonomethyl)pentanedioic acid
• InChIKey: ISEYJGQFXSTPMQ-UHFFFAOYSA-N
• INCHI: 1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)
• 異性体SMILES: C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
• RTECS: SA0454800
• PubChem CID: 10130754
• 分子量: 226.12

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 分類 Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 分類: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Fatty acids and conjugates Organic phosphonic acids Carboxylic acids Organophosphorus compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid - Dicarboxylic acid or derivatives - Organophosphonic acid derivative - Organophosphonic acid - Carboxylic acid - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• 説明: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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作用メカニズム

化学的性質と物理的性質

• 溶解度: Soluble to 100 mM in sterile water
• 感度: Moisture sensitive
• 分子量: 226.120 g/mol
• XLogP3: -2.200
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 226.024 Da
• Monoisotopic Mass: 226.024 Da
• Topological Polar Surface Area: 132.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 267.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1