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4-Methylhistamine - Moligand™,≥95% , Agonist of H 4 receptor, CAS No.36507-31-0, Agonist of H 4 receptor

CAS: 36507-31-0 Cat. No.: M607190 Molecular Weight: 125.17 EC Number: 635-740-9
COA
4-Methylhistamine - Moligand™,≥95% CAS No(36507-31-0) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
Synonyms
2-(5-Methyl-4-imidazolyl)ethylamine | 2-(5-methyl-1H-imidazol-4-yl)ethanamine | FT-0736440 | IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL- | GTPL1269 | Methylhistamine-4 | PDSP1_000400 | 2-(5-METHYL-3H-IMIDAZOL-4-YL)-ETHYLAMINE | C17929 | 5-(2-Aminoethyl)-4-methy
Storage
Room temperature,Argon charged
Shipped In
Normal
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 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
M607190-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$43.90
5mg
M607190-5mg
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$1,300.90
25mg
M607190-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

$1,714.90

$2,000.90
Save $286.00 (14.29%)
100mg
M607190-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90
500mg
M607190-500mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$1,299.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

Moligand™,≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature,Argon charged Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

4-Methylhistamine is a potent and selective agonist of histamine 4 receptor (H4R) with a Ki of 50 nM. 4-Methylhistamine has a >100-fold selectivity for the hH4R over the other histamine receptor subtypes. 4-Methylhistamine can potently activate the hH4R (pEC50 = 7.4). 4-Methylhistamine can be used for the researches of cancer, inflammation and immunology, such as lung cancer and skin inflammation

Specifications

Synonyms
2-(5-Methyl-4-imidazolyl)ethylamine | 2-(5-methyl-1H-imidazol-4-yl)ethanamine | FT-0736440 | IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL- | GTPL1269 | Methylhistamine-4 | PDSP1_000400 | 2-(5-METHYL-3H-IMIDAZOL-4-YL)-ETHYLAMINE | C17929 | 5-(2-Aminoethyl)-4-methy
Specifications & Purity
Moligand™, ≥95%
Storage
Room temperature, Argon charged
Shipped In
Normal
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of H 4 receptor
Purity
≥95%
Product Properties
ALogP-0.2
Names and Identifiers
Canonical SmilesCc1c(CCN)nc[nH]1
IUPAC Name2-(5-methyl-1H-imidazol-4-yl)ethanamine
InChIKeyUGYXPZQILZRKJJ-UHFFFAOYSA-N
INCHI1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
Isomeric SMILES CC1=C(N=CN1)CCN
Alternate CAS 36376-47-3
Molecular Weight 125.17

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic nitrogen compounds
ClassOrganonitrogen compounds
SubclassAmines
Intermediate Tree Nodes Primary amines
Direct Parent2-arylethylamines
Alternative Parents Aralkylamines  Imidazoles  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Monoalkylamines  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents 2-arylethylamine - Aralkylamine - Heteroaromatic compound - Imidazole - Azole - Azacycle - Organoheterocyclic compound - Organopnictogen compound - Hydrocarbon derivative - Primary aliphatic amine - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 2-arylethylamines. These are primary amines that have the general formula RCCNH2, where R is an organic group.
External Descriptors a small molecule
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
HRH4 Tchem Histamine H4 receptor (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hrh4 Histamine H4 receptor (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Molecular Weight125.170 g/mol
XLogP3-0.200
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass125.095 Da
Monoisotopic Mass125.095 Da
Topological Polar Surface Area54.700 Ų
Heavy Atom Count9
Formal Charge0
Complexity84.400
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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Amine (397) H4 receptor Agonist (18)
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