(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC 50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells
Form:Solid
IC50& Target:IC50: 0.6 μM (DGKα)
その他の情報
| CAS | 1815598-71-0 |
|---|---|
| 仕様と純度 | ≥95% |
| 保管条件 | Store at -20°C |
| 入荷 | Ice chest + Ice pads |
| Product Description | (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC 50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells Form:Solid IC50& Target:IC50: 0.6 μM (DGKα) |
| 溶解度 | DMSO : 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C) |
| PubChem CID | 6393804 |
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