(5Z,2E)-CU-3 - 10mM in DMSO , CAS No.1815598-71-0

CAS: 1815598-71-0 Cat. No.: C656406 Molecular Weight: 392.47 PubChem CID: 6393804

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC 50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells

IC50& Target:IC50: 0.6 μM (DGKα)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

(5Z, 2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC 50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K m value of 0.48 mM. (5Z, 2E)-CU-3 targets the catalytic region, but not the regulatory

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)S(=O)(=O)NN2C(=O)/C(=C/C=C/C3=CC=CO3)/SC2=S
• PubChem CID: 6393804
• MeSH Entry Terms: 5-(3-(2-furyl)prop-2-enylidene)-3-((phenylsulfonyl)amino)-2-thioxo-1,3-thiazolidin-4-one;CU-3 thiazolidine compound
• Molecular Weight: 392.47