Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™,≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Solutions should be freshly prepared and protected from exposure to light.
6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.
product description:
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
| Canonical Smiles | C1=C(C(=CC(=C1O)O)O)CCN.Br |
|---|---|
| IUPAC Name | 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide |
| InChIKey | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| INCHI | 1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H |
| Isomeric SMILES | C1=C(C(=CC(=C1O)O)O)CCN.Br |
| WGK Germany | 3 |
| RTECS | DC4600000 |
| Molecular Weight | 250.09 |
| Beilstein | 3713280 |
| Reaxy-Rn | 3713280 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3713280&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Phenols |
| Subclass | Benzenediols |
| Intermediate Tree Nodes | Catechols |
| Direct Parent | Catecholamines and derivatives |
| Alternative Parents | Phenethylamines Hydroxyquinols and derivatives 2-arylethylamines Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Polyols Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives Hydrobromides |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Catecholamine - Hydroxyquinol derivative - Phenethylamine - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Polyol - Primary amine - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrobromide - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as catecholamines and derivatives. These are compounds containing 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] or a derivative thereof formed by substitution. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 05, 2025 | H197233 | |
| Certificate of Analysis | Nov 05, 2025 | H197233 | |
| Certificate of Analysis | Jun 09, 2025 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Sep 02, 2022 | H197233 | |
| Certificate of Analysis | Dec 20, 2021 | H197233 | |
| Certificate of Analysis | Dec 20, 2021 | H197233 | |
| Certificate of Analysis | Dec 20, 2021 | H197233 |
| Solubility | Soluble in DMSO, highest concentration (mg/mL): 50, highest concentration (mM): 199.93; soluble in H2O, highest concentration (mg/mL): 50, highest concentration (mM): 199.93; soluble in Ethanol, highest concentration (mg/mL): 50, the highest concentration |
|---|---|
| Sensitivity | Light & Moisture & Air & Heat sensitive |
| Melt Point(°C) | 216-220°C |
| Molecular Weight | 250.090 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 249 Da |
| Monoisotopic Mass | 249 Da |
| Topological Polar Surface Area | 86.700 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 142.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| 1. Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba. (2023) Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, [PMID:37495085] [10.1016/j.bbadis.2023.166814] |
| 2. Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao. (2022) Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:36562659] [10.1021/acs.jafc.2c06630] |
| 3. Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen. (2022) Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease. JOURNAL OF PROTEOME RESEARCH, [PMID:35959672] [10.1021/acs.jproteome.2c00149] |
| 4. Baoxiang Wang, Lihua Geng, Jing Wang, Yuxi Wei, Changhui Yan, Ning Wu, Yang Yue, Quanbin Zhang. (2024) Optimization of the Preparation Process of Glucuronomannan Oligosaccharides and Their Effects on the Gut Microbiota in MPTP-Induced PD Model Mice. Marine Drugs, 22 (5): (193). [PMID:38786584] [10.3390/md22050193] |
| 5. Zhang Jia-qi, Li Shu-yi, Yin Cui, Ji Ying, Zhang Xiang, Liu Dan-yang, Yang Hang, Niu Yong, Cui Gui-yun, Zhou Chun-yi, Xiao Cheng. (2025) Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice. ACTA PHARMACOLOGICA SINICA, [PMID:40329003] [10.1038/s41401-025-01570-2] |
| 6. Zuowen Zhang, Lan Shen, Yinyou Bai, Shishuang Li, Shumei Wang. (2025) WuMei-pill alleviates Parkinson's disease induced by dopamine neuron damage in mice by regulating the gut-brain-microbiome axis. Journal of Radiation Research and Applied Sciences, [PMID:] [10.1016/j.jrras.2025.101632] |
| 7. Zang Hao-Jing, Bai Xiao-Lin, Sui Xue-Yi, Zhai Xiao-Rui, Wang Yong-Cui, Xin Zhong-Quan, Yin Qiu-Yuan, Hao Xiao-Jiang, Wang Yue-Hu, Liao Xun, Di Ying-Tong. (2025) Neuroprotective effects of chemical constituents from Nicotiana tabacum L. in Parkinson’s disease. Natural Products and Bioprospecting, 15 (1): (1-13). [PMID:41028298] [10.1007/s13659-025-00541-8] |
| 8. Zizhao Zhai, Wenhao Wang, Guanlin Wang, Chunfu Wei, Shuhua Wei, Jinxia Li, Lingling Zheng, Xiao Yue, Chuangxin Chen, Junhuang Jiang, Bing Zhu, Ziyu Zhao, Xin Pan, Chuanbin Wu, Xuejuan Zhang. (2026) Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays. JOURNAL OF CONTROLLED RELEASE, [PMID:41617015] [10.1016/j.jconrel.2026.114667] |
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