AB3067 , CAS No.A1429378

CAS: A1429378 Cat. No.: A1429378 分子式: C₇₄H₉₁ClFN₁₁O₁₇S₂ 分子量: 1525.16

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

AB3067 is a PROTAC degrader for BET protein , that recruits two different E3 ligase Cereblon and VHL with good affinity ( IC 50 =559 nM for VHL in live HEK293; IC 50 =190 nM for CRBN in live HEK293), and degrades BRD2 , BRD3 , BRD4 and CRBN with DC 50 of 2.1~2.3, 1.6, 15 and 75 nM, respectively. AB3067 inhibits the proliferation of RKO cell with an EC 50 of 111 nM. (Pink: ligand for target protein ; Black: linker ; Blue: ligand for E3 ligase VHL and CRBN)

仕様

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

DEGRADER

名前と識別子

分子量

1525.16