Abaloparatide TFA - ≥96% , CAS No.A658609

CAS: A658609 Cat. No.: A658609 分子式: C₁₇₆H₃₀₁N₅₆F₃O₅₁ 分子量: 4074.61

グレード＆純度 ≥96%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation

Appearance:Solid

IC50& Target:Parathyroid hormone receptor 1 (PTHR1)

In Vitro:Abaloparatide TFA (0-100 nM; 40 min) enhances Gs/cAMP signaling and β-arrestin recruitment in MC3T3-E1 cells. Abaloparatide TFA (0-100 nM) efficiently induces PTHR1 internalization in a dose-dependen manner with an EC 50 value of 0.8 nM in U2OS Cell

In Vivo:Abaloparatide TFA (20-80 µg/kg; s.c.; daily for 30 days) enhances bone formation and cortical structure in mouse. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague-Dawley rats

Biological Activity:Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation

仕様

仕様と純度

≥96%

保管条件

Protected from light,Argon charged,Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

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アクションタイプ

ACTIVATOR

純度

≥96%

名前と識別子

分子量

4074.61

化学的性質と物理的性質

• 溶解度: H2O : ≥ 50 mg/mL (12.27 mM)