Abemaciclib metabolite M2 - ≥99% , CAS No.1231930-57-6

CAS: 1231930-57-6 Cat. No.: A650455 分子式: C₂₅H₂₈F₂N₈ 分子量: 478.54

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC 50 s of 1.2 and 1.3 nM, respectively. Anti-cancer activity

In Vivo

Abemaciclib metabolite M2 (LSN2839567) is bound to plasma proteins in rat, dog and human (83-92%), lower than Abemaciclib (95-99%). Abemaciclib metabolite M2 is the most prominent (active and major) plasma metabolites in human. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CDK4 1.2 nM (IC 50 ) CDK6 1.3 nM (IC 50 )

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC 50 s of 1.2 and 1.3 nM, respectively. Anti-cancer activity.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 478.54

化学的性質と物理的性質

• 溶解度: DMSO : 2 mg/mL (4.18 mM; Need ultrasonic)