Abiraterone - Moligand™, 10 mM in Ethanol , CAS No.154229-19-3

CAS: 154229-19-3 Cat. No.: A1499175 分子式: C₂₄H₃₁NO 分子量: 349.52 EC番号: 810-941-6

GRADE & PURITY Moligand™, 10 mM in Ethanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC 50 s of 2.5 nM and 15 nM, respectively.

Specifications

仕様と純度

Moligand™, 10 mM in Ethanol

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

製品の性質

• ALogP: 4.6

名前と識別子

• 異性体SMILES: C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O
• 分子量: 349.52
• Reaxy-Rn: 25096948
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25096948&ln=

参考文献

1. Fulin Bi, Yan Lin, Baohong Zhang, Zishan Chen, Jixia Li, Tong Yuan, Jin Yang.  (2025)  Establishing clinically relevant dissolution specifications for prodrug bioequivalence risk assessment: Integration of a dissolution/permeation system with physiologically based biopharmaceutics modeling in abiraterone acetate.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:40925492] [10.1016/j.ejpb.2025.114857]