AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC 50 : 40 μM). AD-2646 triggers the cleavage of caspase-8 , -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism.
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