AD57 - ≥98% , CAS No.1093380-42-7

CAS: 1093380-42-7 Cat. No.: A651331 分子式: C₂₂H₂₀F₃N₇O 分子量: 455.44

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity

In Vitro

AD57 (0.2 nM) significantly inhibits the ptc > dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances survival of ptc > dRet MEN2B by reducing erk gene dosage in Drosophila. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RET MEN2 models . AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Braf

Specifications

仕様と純度

≥98%

生化学的・生理学的メカニズム

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity.

保管条件

Protected from light,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

• 分子量: 455.44

化学的性質と物理的性質

• 溶解度: DMSO : 125 mg/mL (274.46 mM; Need ultrasonic)