Alizarin(1,2-DHAQ) - Moligand™,10mM in DMSO , CAS No.72-48-0

CAS: 72-48-0 Cat. No.: A408093 分子式: C₁₄H₈O₄ 分子量: 240.21 Beilstein Registry Number: 1914037 EC番号: 200-782-5

グレード＆純度 Moligand™, 10mM in DMSO

Synonyms

Anthraquinonic | 1,​2-​dihydroxy-9,​10-​anthracenedione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 andCYP1B1withIC50of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
In vitro

Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 with K_i of 0.5 μM. Alizarin reduces the mutagenicity of MeIQx, which induced by each CYP1A2 or CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes.

In vivo

Alizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level of alanine aminotransferase in poisoned animals.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

仕様

同義語

Anthraquinonic | 1,​2-​dihydroxy-9,​10-​anthracenedione

仕様と純度

Moligand™,10mM in DMSO

生化学的・生理学的メカニズム

Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

名前と識別子

異性体SMILES

C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3)O)O

WGKドイツ

3

RTECS

CB6580000

分子量

240.21

Beilstein

1914037

Reaxy-Rn

1914037

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1914037&ln=

関連ターゲット（人間）

CYP1B1 Tchem Cytochrome P450 1B1 (1 Activities)

Discover Target: CYP1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro
• 沸点（°C）: 430°C
• 融点（°C）: 290°C