Allo-aca - ≥99% , CAS No.A658698

CAS: A658698 Cat. No.: A658698 分子式: C₄₈H₇₅N₁₃O₁₅ 分子量: 1074.19

グレード＆純度 ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

Appearance:Solid

In Vitro:Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC 50 of 200 pM. Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression

In Vivo:In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and mg/kg/day doses, respectively. MCE has not ind

Biological Activity:Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models .

仕様

仕様と純度

≥99%

保管条件

Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

純度

≥99%

名前と識別子

分子量

1074.19

化学的性質と物理的性質

• 溶解度: H2O : 50 mg/mL (46.55 mM; Need ultrasonic)