Aloxistatin (E64d) - Moligand™, 10mM in DMSO , Inhibitor of cathepsin G, CAS No.88321-09-9, Inhibitor of cathepsin G

CAS: 88321-09-9 Cat. No.: A409190 分子式: C₁₇H₃₀N₂O₅ 分子量: 342.43 EC番号: 635-831-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

E-64d | 3-​[[[(1S)-​3-​methyl-​1[[(3S-​methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-​2S-​oxiranecarboxylic acid,​ ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Aloxistatin (E64d) Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin tr
In vitro

Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain. Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro.

In vivo

Aloxistatin (100 mg/kg, p.o.) strongly inhibits the cathepsin B&L activities in the skeletal muscle, heart and liver of hamsters. In spinal cord injury (SCI) rats, Aloxistatin provides neuroprotection in SCI lesion and penumbra. Aloxistatin reduces brain amyloid-β and improves memory deficits in Alzheimer\'s disease animal models by inhibiting cathepsin B activity.
Cell Data

cell lines：PTC cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

同義語

E-64d | 3-​[[[(1S)-​3-​methyl-​1[[(3S-​methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-​2S-​oxiranecarboxylic acid,​ ethyl ester

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellu

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of cathepsin G

名前と識別子

異性体SMILES

CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

分子量

342.43

Reaxy-Rn

25759192

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25759192&ln=

関連ターゲット（人間）

CTSG Tchem Cathepsin G (0 Activities)

Discover Target: CTSG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 100 mg/mL (158.31 mM); Ethanol: 40 mg/mL (63.32 mM); Water: Insoluble
• 比旋光度［α］: 49° (C=1,MeOH)
• 融点（°C）: 126 °C