AM-6538 - ≥99% , CAS No.1245626-00-9

CAS: 1245626-00-9 Cat. No.: A649958 分子式: C₂₆H₂₅Cl₂N₅O₄ 分子量: 542.41

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may be useful in future studies that require temporary reductions in cannabinoid receptor availability

In Vitro

AM6538 is a cannabinoid antagonist that binds CB1 receptors expressed in HEK-293 cells in a wash-resistant manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AM6538 (1~10 mg/kg) antagonizes the antinociceptive effects of cannabinoid agonists in mice . AM6538 (10 mg/kg) shows that there are some recovery in the effects of AM4054. AM6538 dose dependently decreases the tau values for all cannabinoid agonists, reflecting reductions in the available receptors. AM6538 produces enduring antagonism, with robust effects on the tetrahydrocannabinol dose-effect function evident up to 7 days after treatment . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:cannabinoid

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

ANTAGONIST

純度

≥99%

名前と識別子

• 分子量: 542.41

化学的性質と物理的性質

• 溶解度: DMSO : 50 mg/mL (92.18 mM; Need ultrasonic)