Amelubant - Moligand™, 10mM in DMSO , CAS No.346735-24-8

CAS: 346735-24-8 Cat. No.: A656235 Molecular Weight: 538.63

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Amelubant (BIIL 284) is a potent, oral and long acting LTB 4 receptor antagonist, negligibly binds to LTB 4 receptor, with K i s of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity

In Vitro

Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB 4 receptor antagonists, with K i s of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:LTB 4 221 nM (Ki, in vital human granulocytes) LTB 4 230 nM (Ki, in cell membranes)

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Amelubant (BIIL 284) is a potent, oral and long acting LTB 4 receptor antagonist, negligibly binds to LTB 4 receptor, with K i s of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Names and Identifiers

• Isomeric SMILES: CCOC(=O)NC(=N)C1=CC=C(C=C1)OCC2=CC(=CC=C2)COC3=CC=C(C=C3)C(C)(C)C4=CC=C(C=C4)O
• Molecular Weight: 538.63
• Reaxy-Rn: 10735684
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10735684&ln=