Amitriptyline Hydrochloride - ≥98% , Norepinephrine transporter inhibitor, CAS No.549-18-8, Norepinephrine transporter inhibitor

CAS: 549-18-8 Cat. No.: A129730 分子式: C20H23N · HCl 分子量: 313.86 EC番号: 208-964-6
注文可能
グレード&純度 ≥98%
Synonyms
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride|AMITRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH]|Amyline|Novoprotect|Tryptizol retard|AMITRIPTYLINE HYDROCHLORIDE (EP IMPURITY)|Larozyl|Tripta|Saroten Retard|Teperin|ETRAFON-A COMPONENT AMITRIPTYLINE HYDROCHLORIDE|Sarotex|AMITRIPTYLINE HYDROCHLORIDE [USP-RS]|Tridep|AMITRIPTYLINE HYDROCHLORIDE [EP IMPURITY]|Mitaptyline|Saroten|Trynol|LIMBITROL COMPONENT AMITRIPTYLINE HYDROCHLORIDE|5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride|5-(3-(Dimethylamino)propylidene) dibenzosuberane HCl|Amitriptyline hydrochloride [USP:JAN]|Amitriptyline-13C3Hydrochloride|Annolytin|Apo-Amitriptyline|Levate|Nornaln|Lentizol|Maxivalet|Tryptacap hydrochloride|Amitriptyline hydrochloride|Pinsanu|Ami-Anelun|Amitryptiline hydrochloride|Amyzol|Etrafon|Limbitrol DS|sk-Amitriptyline chloride|Amitriptyline (hydrochloride)|Novotriptyn|Proheptadien monohydrochloride|Syneudon|Triavil|Yamanouchi|1-propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride|Annoyltin|Elatrol|Trepiline|Endep|Pinsaun|AMITRIPTYLINE HYDROCHLORIDE [EP MONOGRAPH]|Domical|1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride|Amitriptyline HCl|Enafon|Kyliran|Trytomer|AMITRIPTYLINE HCL (D6)|Amitril|AMITRIPTYLINE HYDROCHLORIDE (MART.)|AMITRIPTYLINE HYDROCHLORIDE [MART.]|Amiprin|5-(3-Dimethylaminopropylidene)dibenzo(a,d)(1,4)cycloheptadiene hydrochloride|Elatrolet|Amavil|Amilit|Amineurin|Daprimen|Elavil hydrochloride|LIMBITROL DS COMPONENT AMITRIPTYLINE HYDROCHLORIDE|Miketorin|Tryptine|Oasil-M|Tryptizol|Amiplin|AMITRIPTYLINE HYDROCHLORIDE (USP MONOGRAPH)|AMITRIPTYLINE HYDROCHLORIDE (USP-RS)|3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride|3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride|AMITRIPTYLINE HYDROCHLORIDE [USP IMPURITY]|Rantoron|Amitid|AMITRIPTYLINE HYDROCHLORIDE (USP IMPURITY)|Amitriptyline hydrochloride (USP:JAN)|Sarotena|Vanatrip|ADT-Zimaia|Belpax|AMITRIPTYLINE HYDROCHLORIDE (EP MONOGRAPH)|Amitryptyline hydrochloride|Anapsique|Damilen hydrochloride
Storage
Store at 2-8°C,Protected from light
Shipped In
Wet ice
★
サイズ
USA
ドイツ (EU)*
価格
個数
1g
A129730-1g
2 在庫あり
—
$17.90
5g
A129730-5g
4 在庫あり
—
$39.90
25g
A129730-25g
9 在庫あり
—
$92.90
100g
A129730-100g
2 在庫あり
—
$339.90
Enter a quantity for the sizes you want to add.

概要

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.

仕様

同義語
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride | AMITRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH] | Amyline | Novoprotect | Tryptizol retard | AMITRIPTYLINE HYDROCHLORIDE (EP IMPURITY) | Larozyl | Tripta | Saroten Retard | Teperin | ETRAFON-A COMPONENT AMITRIPTYLINE HYDROCHLORIDE | Sarotex | AM もっと見る
仕様と純度
≥98%
生化学的・生理学的メカニズム
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.Serotonin and noradrenalin uptake
保管条件
Store at 2-8°C,Protected from light
入荷
Wet ice
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
作用メカニズム
Norepinephrine transporter inhibitor
注
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
純度
≥98%
名前と識別子
パブケム・シド
パブケム・シド・ウル
https://pubchem.ncbi.nlm.nih.gov/substance/488181249
カノニカル・スマイル
CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
IUPAC Name
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride
InChIKey
KFYRPLNVJVHZGT-UHFFFAOYSA-N
INCHI
1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
異性体SMILES
CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
WGKドイツ
3
RTECS
HO9450000
代替CAS番号
50-48-6
分子量
313.86
Reaxy-Rn
4164595
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4164595&ln=

詳細データ

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
分類Dibenzocycloheptenes
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentDibenzocycloheptenes
Alternative Parents Trialkylamines  Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homopolycyclic compounds
Substituents Dibenzocycloheptene - Tertiary aliphatic amine - Tertiary amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
説明This compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





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作用メカニズム
証明書(CoA、COO、BSE/TSEと分析図)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot NumberCertificate Type日付商品
C2304019C2304019Certificate of AnalysisSep 01, 2026 A129730
C2304022C2304022Certificate of AnalysisSep 01, 2026 A129730
C23031322C23031322Certificate of AnalysisSep 01, 2026 A129730
F2617617F2617617Certificate of AnalysisMay 09, 2026 A129730
F2612417F2612417Certificate of AnalysisMay 09, 2026 A129730
F2612416F2612416Certificate of AnalysisMay 09, 2026 A129730
F2612402F2612402Certificate of AnalysisMay 09, 2026 A129730
F2413069F2413069Certificate of AnalysisMar 18, 2026 A129730
H2204270H2204270Certificate of AnalysisFeb 04, 2026 A129730
H2204271H2204271Certificate of AnalysisFeb 04, 2026 A129730
D2614059D2614059Certificate of AnalysisMar 21, 2025 A129730
D2529279D2529279Certificate of AnalysisMar 21, 2025 A129730
D2518257D2518257Certificate of AnalysisMar 21, 2025 A129730
D2518255D2518255Certificate of AnalysisMar 21, 2025 A129730
D2518254D2518254Certificate of AnalysisMar 21, 2025 A129730
C2624018C2624018Certificate of AnalysisMar 21, 2025 A129730
H2204272H2204272Certificate of AnalysisMay 07, 2024 A129730
H2204273H2204273Certificate of AnalysisMay 07, 2024 A129730
化学的性質と物理的性質
溶解度Soluble in Chloroform
感度Light sensitive;Moisture sensitive
融点(°C)195 °C
分子量313.900 g/mol
XLogP3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Exact Mass313.16 Da
Monoisotopic Mass313.16 Da
Topological Polar Surface Area3.200 Ų
Heavy Atom Count22
Formal Charge0
Complexity331.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
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