AND-302 , CAS No.1380201-88-6

CAS: 1380201-88-6 Cat. No.: A1449116 分子式: C₈H₉F₃N₂O₂S 分子量: 254.23

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

AND-302 is a small molecule anticonvulsant with activity in preventing glutamate- or hydrogen peroxide-induced cell death and decreased neuronal viability in in vitro hippocampal cultures.

Specifications

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

分子量

254.23

Application Protocols

Validated application protocols, recommended concentrations, and positive controls are not provided for AND-302 in the product data.

General starting points (not item-specific):

• Stock solutions: Commonly 10–50 mM in DMSO for small molecules; confirm solubility and stability first.
• In vitro biochemical assays: Begin with a broad concentration range (e.g., 0.1 nM–100 µM) depending on expected potency; include vehicle and blank controls.
• Cell-based assays: Titrate to identify non-toxic concentration windows; maintain vehicle ≤0.1–0.5% v/v.
• Data quality: Include replicates, assess precipitation visually (or by light scattering), and document lot and handling.

Users should obtain or request the CoA/Spec Sheet for any item-specific directions before initiating experiments.

Biological Roles

Specific biological function, target class, and pathway involvement for AND-302 are not provided in the product data.

• Mechanism of action: Not specified for this item; refer to CoA/Spec Sheet and primary literature for AND-302.
• Target/pathway: Not specified for this item; refer to CoA/Spec Sheet.
• Potency/kinetics: Not specified for this item; refer to CoA/Spec Sheet.

General guidance for life-science small molecules (not item-specific):

• Verify identity and purity prior to biological testing (LC–MS, 1H NMR). Degradation can confound assay results.
• Establish solubility and vehicle effects in your assay system; include vehicle-only controls at the maximum vehicle percentage.
• Conduct preliminary cytotoxicity or general viability assays (e.g., resazurin, CellTiter-Glo) to define non-toxic concentration ranges if using live cells.
• Record lot numbers and exact handling conditions; many bioactives are sensitive to light, oxidation, or repeated freeze–thaw cycles.

Note: All uses are for research only (as provided). No clinical or diagnostic use is implied.

Buffer Applications

Buffer formulation guidance is not applicable without knowledge of the compound’s ionization state and intended assay.

• Buffer use: Not specified for this item; refer to CoA/Spec Sheet.

General notes (not item-specific):

• If preparing aqueous working solutions, select buffer pH relative to the compound’s pKa (if known) to maintain solubility and stability.
• Common biological buffers (HEPES, PBS, Tris) may interact with certain functional groups or metal-binding motifs; confirm compatibility experimentally.
• Filter sterilize only if the compound is stable toward the filtration membrane and shear.

If no aqueous solubility is achievable, consider maintaining concentrated DMSO or ethanol stocks and diluting into buffer immediately before use to limit precipitation.

Green Alternatives

A green-chemistry assessment requires knowledge of structure, functional class, and solvent/auxiliary use—all not provided for AND-302.

General considerations (not item-specific):

• If the reagent is used only as a biological probe at milligram-to-microgram scale, its direct environmental footprint is dominated by the choice of solvents and disposables. Prefer water or biocompatible buffers where feasible; minimize high-toxicity aprotic solvents (e.g., DMF, NMP) and halogenated wastes.
• For stock solutions, consider ethanol or aqueous cyclodextrin carriers as greener alternatives to DMSO when compatible with the compound and assay.
• Implement microscale assays and high-density plate formats to reduce solvent consumption.

Example solvent substitution hierarchy (general):

• More preferable: water/buffer, ethanol, isopropanol.
• Use with care: acetone, ethyl acetate, acetonitrile, methanol.
• Avoid when possible: DMF, NMP, dichloromethane, chloroform (except where strictly necessary and controlled).

Recommendation: Consult your institutional green-chemistry guidelines and the CoA/SDS for AND-302 to identify any specific hazards or solvent compatibilities that inform greener choices.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or manufacturing application is provided for AND-302 in the product data. This product is designated For research use only.

• Regulatory status: Not for human or veterinary use; not for clinical or diagnostic procedures.
• Pharmacopeia listings (USP/EP/JP): Not specified for this item; refer to CoA/Spec Sheet.

General context (not item-specific):

• Many discovery-stage small molecules are handled exclusively in preclinical research labs. If a formulation study is intended (e.g., for in vitro dosing), typical vehicles include DMSO, PEG-containing mixtures, or surfactant systems; selection depends on compound solubility and stability.
• Do not extrapolate any research findings to therapeutic use. Follow institutional review and safety protocols for any in vivo research.

Physical Properties

Item-specific physical properties are not disclosed in the provided data for AND-302 (CAS 1380201-88-6).

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility (water/organic): Not specified for this item; refer to CoA/Spec Sheet.
• LogP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• pKa: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not applicable (typically for liquids); otherwise not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/practice, not item-specific):

• Many life-science small molecules are supplied as solids and are commonly soluble in DMSO at 10–50 mM stock concentrations; aqueous solubility varies with ionizable groups.
• If solubility is unknown, perform a small-scale solubility screen (DMSO, DMF, ethanol, water, buffers across pH 4–9). Start at 1–5 mg/mL.
• Check hygroscopicity or deliquescence empirically: monitor mass change upon brief exposure to ambient conditions.
• Avoid applying any of these general values as specifications; defer to the item’s CoA/Spec Sheet for definitive values.

Quality and Grades

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

How to interpret grades (general guidance):

• Research grade: Suitable for general laboratory use; impurities and UV profile are controlled to typical research standards but may not meet pharmacopeial monograph criteria.
• HPLC grade (solvents) / ≥98–99% chemical purity (solids): Often used when low background in analytical assays is critical. Purity thresholds and impurity profiles should be confirmed on the CoA.
• Bioactive small molecules may also be provided with additional attributes such as salt form, residual solvent limits, water content (KF), and LC–MS purity. These are item-specific and must be verified on the CoA.

What to check on receipt (practical tips):

• Confirm catalog number (A1449116), lot number, and storage temperature label (-20°C) match paperwork.
• Review CoA for: purity method/threshold, identity confirmation (NMR/HRMS), residual solvents, water content, and if applicable, counterion content for salts.
• If your application is assay-sensitive (e.g., cell-based), consider performing an in-house LC–MS/UPLC check for purity and degradation after first thaw.

Reaction and Applications

This product is categorized under Life Science reagents, and no structural or functional information is provided to support use as a synthetic reagent. As such, classical synthetic “reaction applications” (e.g., cross-coupling, oxidations, reductions) are not typically applicable without confirmed structure and reactivity.

If AND-302 is intended as a bioactive probe or screening compound (common for life-science catalog items):

• Applications typically include target engagement assays, cell-based phenotypic screens, or biochemical inhibition/activation studies. Specific targets, potencies, and recommended assay conditions are not provided and must be sourced from the CoA or primary literature for AND-302.

For users considering chemical derivatization:

• Without structural disclosure, do not attempt transformation chemistry. Obtain structural data and assess functional group compatibility, stability (pH/oxidation/light), and potential for epimerization or hydrolysis.

Bottom line: Treat AND-302 as a research-use reagent for biological experimentation pending further documentation; do not assign it to specific synthetic reaction classes without the item’s structural information.

Reaction Conditions

Typical reaction conditions cannot be recommended for AND-302, as no structure or reactive functionality is provided in the product data.

General analytical/handling conditions (not item-specific):

• For solution preparations, use anhydrous solvents if moisture sensitivity is suspected. Work under inert gas when handling potentially air-sensitive materials.
• Monitor stability over time at room temperature versus refrigerated/frozen states to determine workable bench-time windows for assays.
• For any transformation or conjugation chemistry (if later justified by structure), run small-scale trials (≤5 mg) to establish compatibility with bases/acids, catalysts, or coupling reagents.

Note: Defer to the CoA/Spec Sheet and SDS for any item-specific recommendations.

Safety and Handling

Hazard classification for AND-302 is not provided in the product data. Always consult the SDS for authoritative information.

• GHS classification: Not specified for this item; refer to SDS.
• Signal word: Not specified for this item; refer to SDS.
• Hazard statements (H-codes): Not specified for this item; refer to SDS.
• Pictograms: Not specified for this item; refer to SDS.

General laboratory precautions (good practice):

• Use in a chemical fume hood; avoid inhalation, ingestion, and skin/eye contact.
• PPE: lab coat, safety glasses, and appropriate chemical-resistant gloves (e.g., nitrile). Consider double-gloving for DMSO stocks to limit dermal transport.
• Incompatibilities: Unknown without structure. As a precaution, segregate from strong oxidizers, strong acids/bases, and reactive metals until compatibility is known.
• Spill/cleanup: Absorb with inert material, collect for disposal; decontaminate area with appropriate solvent compatible with the material and surface; ventilate well.
• First aid (overview): Eye/skin contact—rinse with water for at least 15 minutes; remove contaminated clothing. Inhalation—move to fresh air. Ingestion—rinse mouth. Seek medical attention in all cases; provide SDS.
• Waste: Dispose via licensed chemical waste stream in accordance with institutional and regional regulations.

Storage and shipping notes (from product data):

• Storage: Store at -20°C.
• Shipping: Ice chest + ice pads.
• Minimize freeze–thaw cycles by aliquoting upon first use.

Solvent Selection

Solubility and solvent compatibility for AND-302 are not specified in the product data, and no structure is available to infer polarity or ionization.

General selection framework (not item-specific):

• For initial dissolution, DMSO is commonly used for small-molecule life-science reagents due to broad solvency and biological assay compatibility at low final percentages (≤0.1–0.5% v/v). DMF or ethanol can be alternatives where appropriate.
• For aqueous work, consider co-solvent strategies: DMSO or ethanol cosolvent (2–10%), pH adjustment if the compound is ionizable (verify pKa on CoA/literature), or cyclodextrin inclusion if permitted.
• For moisture- or base/acid-sensitive materials, prepare stocks under dry, inert conditions and avoid prolonged exposure to ambient humidity.

Practical steps:

• Perform a micro-scale solubility screen (200–500 µL) across DMSO, ethanol, DMF, and buffered aqueous media (pH 6–8) to determine workable stock concentrations.
• Filter-sterilize through 0.22 µm PTFE/NYLON only if compatible with solvent and compound; avoid PVDF for strong aprotic solvents unless rated.

Note: Do not treat these guidelines as specifications. Use the CoA/Spec Sheet for definitive solvent recommendations, if provided.

Storage and Reconstitution

Storage conditions (from product data):

• Store at -20°C.
• Shipped in an ice chest with ice pads to maintain a cold chain.

General handling best practices (not item-specific):

• Upon receipt, inspect packaging and record lot information. Transfer immediately to −20°C storage.
• Allow container to equilibrate to room temperature in a desiccated environment before opening to minimize condensation ingress.
• Aliquot upon first thaw to avoid repeated freeze–thaw cycles; use low-bind tubes for small volumes.

Reconstitution guidance:

• Recommended solvent and concentration: Not specified for this item; refer to CoA/Spec Sheet.
• If solvent is unspecified, evaluate solubility in DMSO first on a small scale; consider ethanol or aqueous buffer only after confirming compatibility and stability.
• For sterile applications, filter stocks through 0.22 µm PTFE (for organic solvents) or PES/nylon (for aqueous) if the compound is compatible with the membrane.

Stability notes:

• Protect from light if the compound is chromophoric or suspected light-sensitive (common for many bioactives).
• Track freeze–thaw count and bench-time exposure; discard aliquots that show precipitation, color change, or assay drift.

Research use only: Not for human or veterinary use.

Structure and Identity

Overview: This product is listed under Life Science reagents with limited structural disclosure. No definitive structural identifiers are provided in the product data for AND-302 (CAS 1380201-88-6).

• Chemical name: Not specified for this item; refer to CoA/Spec Sheet.
• CAS: 1380201-88-6
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
• Synonyms/Identifiers: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general guidance):

• Functional groups, ring systems, stereochemistry, and ionization state cannot be described without a disclosed structure. If you have a lot- or vendor-specific CoA, use the reported identifiers to confirm identity by NMR, LC–MS, and HRMS.

Recommendations for identity confirmation (general lab practice):

• Acquire LC–MS with single-ion monitoring based on the expected [M+H]+ (if provided on CoA) and verify retention time against a reference standard.
• Collect 1H/13C NMR (solvent per CoA). Assess purity/integrity vs. reported spectra.
• If chiral, verify enantiomeric ratio by chiral HPLC (only if specified on CoA).

Synthetic Utility

Without structural information, AND-302 cannot be positioned within synthetic methodologies or building-block strategies.

• Functional group reactivity: Not specified for this item; refer to CoA/Spec Sheet.
• Named reactions/handles: Not specified for this item; refer to CoA/Spec Sheet.

General considerations (not item-specific):

• If structural data become available and derivatization is desired (e.g., for probe development), assess sites amenable to tag installation (alkynes/azides for click, amines for NHS ester coupling) and evaluate how modifications affect potency and permeability.
• For impurity profiling or stability-indicating methods, develop UPLC with photodiode array and MS detection; conduct stress testing (acid/base, oxidative, thermal, photolytic) to map degradation pathways.

In the absence of a disclosed structure and reactivity profile, treat AND-302 as a finished research reagent rather than a synthetic intermediate.

Target Specificity

No target, epitope, or specificity information is provided for AND-302. This listing is not an antibody or protein reagent, and no bio-target data are available in the product data.

• Target/epitope: Not specified for this item; refer to CoA/Spec Sheet.
• Species reactivity: Not applicable.
• Clone/isotype: Not applicable.

If AND-302 is a small-molecule modulator, consult vendor literature or peer-reviewed publications for target binding data, selectivity panels, and off-target profiling, as applicable.