Angiopeptin TFA - ≥99% , CAS No.2478421-60-0

CAS: 2478421-60-0 Cat. No.: A649928 分子式: C₅₈H₇₃F₆N₁₁O₁₄S₂ 分子量: 1326.39

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst 2 /sst 5 receptor partial agonist with IC 50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research

In Vitro

Angiopeptin (0.1 nM- 10 μM; for 1 h) TFA acts as a partial agonist (pEC 50 =6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst 2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation . Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50% . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 0.26 nM (sst2) and 6.92 nM (sst5)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst 2 /sst 5 receptor partial agonist with IC 50 values of 0.26u2009nM and 6.92u2009nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-lik

保管条件

Desiccated,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

AGONIST

純度

≥99%

名前と識別子

• 分子量: 1326.39

化学的性質と物理的性質

• 溶解度: H2O : 10 mg/mL (7.54 mM; Need ultrasonic)