🌎 Ship to: United States
ナビを呼ぶ
Cart
検索
在庫品はすべて当日発送いたします。
詳細検索
クイックオーダー SDS / CoA Structure 一括およびカスタマイズ
メニュー
アカウント
設定
྾
224,000+ 研究の概要 · Triple ISO certified · COA & SDS すべての製品に適用 · 在庫品は当日出荷

APTO-253 - ≥98% , CAS No.916151-99-0

CAS: 916151-99-0 Cat. No.: A413688 分子式: C22H14FN5 分子量: 367.38
COA
APTO-253 - ≥98% CAS No(916151-99-0) by Aladdin Scientific
注文可能
GRADE & PURITY ≥98%
Synonyms
NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4,5-F)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenan
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
USA
ドイツ (EU)*
Price
Qty
2mg
A413688-2mg
6 在庫あり
—

$23.90

$35.90
保存 $12.00 (33.43%)
5mg
A413688-5mg
9 在庫あり
—

$50.90

$76.90
保存 $26.00 (33.81%)
25mg
A413688-25mg
8 在庫あり
—

$189.90

$284.90
保存 $95.00 (33.35%)
50mg
A413688-50mg
8 在庫あり
—

$317.90

$476.90
保存 $159.00 (33.34%)
100mg
A413688-100mg
6 在庫あり
—

$572.90

$859.90
保存 $287.00 (33.38%)
Enter a quantity for the sizes you want to add.
Bulk / Custom
♡ ウィッシュリスト ⇅ 比較リストに入れる ⎙ Print page
SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
概要 Specifications 製品の性質 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 ソリューション計算機 レビュー
🧪
Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Information

APTO-253 APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21) , promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4) .


Targets

c-Myc ; KLF4

Specifications

同義語
NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4,5-F)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenan
仕様と純度
≥98%
生化学的・生理学的メカニズム
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
純度
≥98%
製品の性質
ALogP
4.287
hba_count
3
HBD数
2
回転可能な結合
1
名前と識別子
パブケム・シド
488197814
パブケム・シド・ウル
https://pubchem.ncbi.nlm.nih.gov/substance/488197814
カノニカル・スマイル
CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
IUPAC Name
2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
InChIKey
NIRXBXIPHUTNNI-UHFFFAOYSA-N
INCHI
1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
異性体SMILES
CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
分子量
367.38
Reaxy-Rn
20465211
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20465211&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Phenanthrolines
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentPhenanthrolines
Alternative Parents Quinolines and derivatives  Indoles  Benzimidazoles  Substituted pyrroles  Pyridines and derivatives  Benzenoids  Aryl fluorides  Imidazoles  Heteroaromatic compounds  Azacyclic compounds  Organonitrogen compounds  Organofluorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 1,10-phenanthroline - Quinoline - Benzimidazole - Indole - Indole or derivatives - Aryl fluoride - Aryl halide - Benzenoid - Substituted pyrrole - Pyridine - Azole - Heteroaromatic compound - Imidazole - Pyrrole - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as phenanthrolines. These are aromatic polycyclic compounds containing the phenanthroline skeleton, which is a derivative of phenanthrene, and consists of two pyridine rings non-linearly joined by a benzene ring.
External Descriptors Not available
3 D構造
インタラクティブ化学構造モデル





関連ターゲット（非人間）
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書（CoA、COO、BSE/TSEと分析図）
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate Type日付商品
E2327762Certificate of AnalysisMar 11, 2026 A413688
E2327763Certificate of AnalysisMar 11, 2026 A413688
E2327765Certificate of AnalysisMar 11, 2026 A413688
E2327767Certificate of AnalysisMar 11, 2026 A413688
E2327768Certificate of AnalysisMar 11, 2026 A413688
E2327769Certificate of AnalysisMar 11, 2026 A413688
E2327770Certificate of AnalysisMar 11, 2026 A413688
E2327771Certificate of AnalysisMar 11, 2026 A413688
E2327772Certificate of AnalysisMar 11, 2026 A413688
E2327774Certificate of AnalysisMar 11, 2026 A413688
化学的性質と物理的性質
溶解度Solubility (25°C) In vitro DMSO: 73 mg/mL (198.7 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO（mg / mL） 最大溶解度73
DMSO（mM） 最大溶解度198.704338831727
水（mg / mL） 最大溶解度＜1
分子量367.400 g/mol
XLogP34.300
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass367.123 Da
Monoisotopic Mass367.123 Da
Topological Polar Surface Area70.300 Ų
Heavy Atom Count28
Formal Charge0
Complexity589.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
ソリューション計算機
レビュー

顧客レビュー

We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our Cookie Policy.

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Terms of Use Cookie Policy Terms and Conditions of Sale Sales Policy
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
Copyright © 2023–present Aladdin Scientific Corp. All rights reserved.