Artemisitene - ≥98% , CAS No.101020-89-7

CAS: 101020-89-7 Cat. No.: A649643 Molecular Weight: 280.32 PubChem CID: 127742

GRADE & PURITY ≥98%

Synonyms

3,6-Dimethyl-9-methylideneoctahydro-12H-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one | Artemisitene | 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6-dimethyl-9-methylene-, (3R-(3alpha,5abeta,6beta,8abeta,12beta,12aR*))- |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.

In Vitro

Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Synonyms

3, 6-Dimethyl-9-methylideneoctahydro-12H-3, 12-epoxypyrano[4, 3-j][1, 2]benzodioxepin-10(3H)-one | Artemisitene | 3, 12-Epoxy-12H-pyrano(4, 3-j)-1, 2-benzodioxepin-10(3H)-one, octahydro-3, 6-dimethyl-9-methylene-, (3R-(3alpha, 5abeta, 6beta, 8abeta, 12beta, 12aR*))- |

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1CCC2C(=C)C(=O)OC3C24C1CCC(O3)(OO4)C
• IUPAC Name: (1R,4S,5R,12S,13R)-1,5-dimethyl-9-methylidene-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
• InChIKey: IGEBZMMCKFUABB-MHVOBNHCSA-N
• INCHI: 1S/C15H20O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8,10-11,13H,2,4-7H2,1,3H3/t8-,10+,11?,13-,14-,15-/m1/s1
• Isomeric SMILES: C[C@@H]1CCC2C(=C)C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C
• PubChem CID: 127742
• Molecular Weight: 280.32

Chemical and Physical Properties

• Solubility: DMSO : ≥ 100 mg/mL (356.74 mM)