AS-99 TFA - ≥99% , CAS No.A659364

CAS: A659364 Cat. No.: A659364 分子式: C₂₉H₃₁F₆N₅O₅S₂ 分子量: 707.71

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

概要

AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor ( IC 50 = 0.79 µM, K d = 0.89 µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusi

Appearance:Solid

IC50& Target:0.79 µM (ASH1L histone methyltransferase)

In Vitro:AS-99 TFA is tested against a panel of 20 histone methyltransferases, including NSD1, NSD2, NSD3, and SETD2. NO significant inhibition is observed at 50 µM of AS-99 TFA on any of the tested histone methyltransferases, indicating over 100-fold selectivity

In Vivo:AS-99 (30mg/kg; i.p.; q.d., treated for 14 consecutive days) TFA reduces leukemia burden in mice. AS-99 TFA is used for in vivo studies in mice, which reveals favorable exposure in plasma upon i.v. and i.p. administration (AUC = 9701 hr* ng/mL and 1

Biological Activity:AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor ( IC 50 =u20090.79u2009µM, K d =u20090.89u2009µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downre

Specifications

仕様と純度

≥99%

保管条件

Store at 2-8°C,Desiccated

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 707.71

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (141.30 mM; Need ultrasonic) H2O : 12.5 mg/mL (17.66 mM; Need ultrasonic)