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· · COA & SDS すべての製品に適用 · 在庫品は当日出荷 ASP 2535 - モリガンド™, ≥95 , Inhibitor of GlyT1, CAS No.374886-51-8, Inhibitor of GlyT1
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95% Synonyms
4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
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Why this grade モリガンド™, ≥95 Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping 20℃で保存 Ships アイスチェスト＋アイスパッド Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
概要 ASP2535は、強力で、選択的、脳透過性かつ中枢に活性なグリシントランスポーター-1（GlyT1）阻害剤である。ASP2535は、統合失調症およびアルツハイマー病の動物モデルにおいて認知機能障害を改善する。
Specifications 同義語
4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
生化学的・生理学的メカニズム
In vitro：ASP2535はラットGlyT1（IC50=92 nM）を強力に阻害し、in vitroではラットグリシントランスポーター-2（GlyT2）に対して50倍の選択性を示す； In vivo：ASP2535（1～3mg/kg、p.o.）はラットにおけるPCP誘発性のプレパルス抑制障害を改善する[1]。ASP2535（0.3～3mg/kg；
作用メカニズム
Inhibitor of GlyT1
名前と識別子 カノニカル・スマイル CC(C)C1=NN=C(N1C2=CC=CC3=NON=C32)C4=CN=C(C=C4)C5=CC=CC=C5 IUPAC Name 4-[3-(6-phenylpyridin-3-yl)-5-propan-2-yl-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole InChIKey FQGLDGKVKDPVLO-UHFFFAOYSA-N INCHI 1S/C22H18N6O/c1-14(2)21-24-25-22(28(21)19-10-6-9-18-20(19)27-29-26-18)16-11-12-17(23-13-16)15-7-4-3-5-8-15/h3-14H,1-2H3 異性体SMILES CC(C)C1=NN=C(N1C2=CC=CC3=NON=C32)C4=CN=C(C=C4)C5=CC=CC=C5 分子量 382.42 Reaxy-Rn 14169852 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14169852&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds 分類 Pyridines and derivatives Subclass Phenylpyridines Intermediate Tree Nodes Not available Direct Parent Phenylpyridines Alternative Parents Pyridyl-1,2,4-triazoles Phenyl-1,2,4-triazoles Benzoxadiazoles Benzene and substituted derivatives Heteroaromatic compounds Furazans Oxacyclic compounds Azacyclic compounds Organonitrogen compounds Organic oxygen compounds Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents 2-phenylpyridine - Pyridyl-1,2,4-triazole - Pyridyltriazole - Phenyl-1,2,4-triazole - Phenyltriazole - Benzoxadiazole - Monocyclic benzene moiety - Benzenoid - Azole - Heteroaromatic compound - Furazan - Oxadiazole - 1,2,4-triazole - Triazole - Oxacycle - Azacycle - Hydrocarbon derivative - Organic oxygen compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound 説明 This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3 D構造 関連ターゲット（人間） 関連ターゲット（非人間） 作用メカニズム 証明書（CoA、COO、BSE/TSEと分析図） 化学的性質と物理的性質 溶解度 Soluble in DMSO to 75 mM and ethanol to 75 mM 分子量 382.400 g/mol XLogP3 3.800 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 4 Exact Mass 382.154 Da Monoisotopic Mass 382.154 Da Topological Polar Surface Area 82.500 Ų Heavy Atom Count 29 Formal Charge 0 Complexity 541.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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