AZD0095 - ≥99% , CAS No.2750001-23-9

CAS: 2750001-23-9 Cat. No.: A651280 分子式: C₂₇H₃₂N₈O₂ 分子量: 500.60

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

AZD0095 is a selective and orally active MCT4 inhibitor ( IC 50 : 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib

In Vitro

AZD0095 (0-50 µM) inhibits cell proliferation in NCI-H358 cells (high expression of MCT4), with an IC 50 of 26 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD0095 (100 mg/kg, p.o. bid) together with Cediranib (3 mg/kg, p.o.) reduces tumor growth in a murine NCI-H358 xenograft . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Murine NCI-H358 xenograft Dosage: 100 mg/kg together with Cediranib (3 mg/kg) Administration: Oral administration (p.o.) Result: Reduced tumor growth more efficiently than AZD0095 or AZD2171 alone.

Form:Solid

IC50& Target:MCT4 1.3 nM (IC 50 )

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

AZD0095 is a selective and orally active MCT4 inhibitor ( IC 50 : 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib ( HY-10205 ).

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 500.60