AZD2461 - Moligand™, 10mM in DMSO , CAS No.1174043-16-3

CAS: 1174043-16-3 Cat. No.: A408089 分子式: C₂₂H₂₂FN₃O₃ 分子量: 395.43 EC番号: 682-440-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

AZD2461 AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
In vitro

AZD2461 has lower affinity for Pgp than does Olaparib.

In vivo

AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

名前と識別子

• 異性体SMILES: COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F
• 分子量: 395.43
• Reaxy-Rn: 19333597
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19333597&ln=

関連ターゲット（人間）

PRAP1 Tchem Proline-rich acidic protein 1 (1 Activities)

Discover Target: PRAP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 (1 Activities)

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)